Maya Hudiyati
1,2 
, Siti Sunarintyas
3* , Retno Ardhani
4 , Alim Isnansetyo
5 1 Student of Doctoral Program, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
2 Study Program of Dentistry, Faculty of Medicine, Universitas Sriwijaya, South Sumatera, Indonesia
3 Department of Dental Biomaterial, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
4 Department of Dental Biomedical Science, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
5 Department of Fisheries, Faculty of Agriculture, Universitas Gadjah Mada, Yogyakarta, Indonesia
Abstract
Fucoidan, produced by the cell walls of brown seaweed, possesses biological effects, covering anticancer, antiviral, anti-inflammatory, antioxidant, and a potential for promoting angiogenesis and osteogenesis. This study aimed to compile diverse scientific results on fucoidan’s therapeutic prospect in dentistry and the mechanism of action in the therapy of oral diseases. A literature search was carried out using keywords with Boolean operators, including fucoidan (AND) oral (OR) dental (OR) dentistry, to identify related publications from PubMed, ScienceDirect, and Google Scholar databases. The results showed that fucoidan had various therapeutic potentials in the field of dentistry, including anticancer, anti-inflammatory, radioprotection, protection of dental pulp tissue, and bone regeneration. These characteristics were related to the sulfate composition and molecular weight. Fucoidan has various therapeutic potentials crucial for oral health. Hence, it might be used for material development and drug production in dentistry
Implication for health policy/practice/research/medical education:
The analysis presents a detailed insight into fucoidan, which has a variety of bioactivities related to oral health. Furthermore, this review categorizes the potential of fucoidan based on the latest published studies, providing a valuable basis for further development of fucoidan-based therapies for oral inflammation, oral cancer, drug delivery, and tissue regeneration in dentistry, as well as for the improvement of dental material properties.
Please cite this paper as: Hudiyati M, Sunarintyas S, Ardhani R, Isnansetyo A. Therapeutic potential of fucoidan in dentistry: A review. J Herbmed Pharmacol. 2024;13(2):188-198. doi: 10.34172/jhp.2024.48302.