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J Herbmed Pharmacol. 2023;12(2): 202-213. doi: 10.34172/jhp.2023.21

Original Article

Apigenin role against thioacetamide-triggered liver fibrosis: Deciphering the PPARγ/TGF-β1/NF-κB and the HIF/FAK/ AKT pathways

Rehab F. Abdel-Rahman 1 * ORCID, Hany M. Fayed 1 ORCID, Marwan Abd Elbaset Mohamed 1 ORCID, Alyaa F. Hessin 1 ORCID, Gihan F. Asaad 1 ORCID, Sahar AbdelRahman 2 ORCID, Abeer A.A. Salama 1 ORCID, Mahmoud S. Arbid 1 ORCID, Hanan A. Ogaly 3 ORCID

Cited by CrossRef: 5

1- Elbaset M, Mohamed B, Moustafa P, Mansour D, Afifi S, Esatbeyoglu T, Abdelrahman S, Fayed H, Franco J. Erythropoietin Suppresses the Hepatic Fibrosis Caused by Thioacetamide: Role of the PI3K/Akt and TLR4 Signaling Pathways. Oxidative Medicine and Cellular Longevity. 2023;2023:1 [Crossref]
2- Wenbo Z, Jianwei H, Hua L, Lei T, Guijuan C, Mengfei T. The potential of flavonoids in hepatic fibrosis: A comprehensive review. Phytomedicine. 2024;133:155932 [Crossref]
3- Elbaset M, Mohamed B, Hessin A, Abd El‐Rahman S, Esatbeyoglu T, Afifi S, Fayed H. Nrf2/HO‐1, NF‐κB and PI3K/Akt signalling pathways decipher the therapeutic mechanism of pitavastatin in early phase liver fibrosis in rats. J Cellular Molecular Medi. 2024;28(3) [Crossref]
4- Mohammed O, Attia H, Mohamed B, Elbaset M, Fayed H. Current investigations for liver fibrosis treatment: between repurposing the FDA-approved drugs and the other emerging approaches. J pharm pharm sci. 2023;26 [Crossref]
5- Alamri Z. Protective and therapeutic effects of apigenin on thioacetamide-induced hepatotoxicity in male rats: physiological and morphological study. Egypt Liver Journal. 2024;14(1) [Crossref]
6- Saad H, Oda S, Alexiou A, Papadakis M, Mahmoud M, Batiha G, Khalifa E. Hepatoprotective activity of Lactéol® forte and quercetin dihydrate against thioacetamide‐induced hepatic cirrhosis in male albino rats. J Cellular Molecular Medi. 2024;28(8) [Crossref]