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J Herbmed Pharmacol. 2023;12(1): 168-175. doi: 10.34172/jhp.2023.17

Original Article

In vivo and in vitro evaluation of antioxidant, antihemolytic, acute toxicity effects and high-performance liquid chromatography analysis of an aqueous extract of Moroccan Punica granatum L.

Ismail Elkoraichi 1 ORCID, Mounia Latif 1 ORCID, Othman El Faqer 1 ORCID, Rajaa Elaje 1,2 ORCID, Abderrahmane Thoume 3 ORCID, El Mostafa Mtairag 1 ORCID, Samira Rais 1,4 * ORCID, Fouad Daoudi 1 ORCID

Cited by CrossRef: 7

1- Ouadghiri Z, El Faqer O, Wahnou H, Soudassi A, Marnissi F, Rais S, Mtairag E. In Vivo and In Vitro Assessment of Marrubium vulgare: Chemical, Antioxidant and Anti-inflammatory Profiles. Arab J Sci Eng. 2026;51(2):1227 [Crossref]
2- El Faqer O, El Faqer A, Elkoraichi I, Ouadghiri Z, Boughroud H, Rais S, El Ouaddari A, El Amrani A, Mtairag E. Phenolic Composition and Preliminary Biological Activities of Moroccan Allium sativum Extracts: In Vitro and In Silico Evidence. Compounds. 2026;6(2):33 [Crossref]
3- Lafdil F, Legssyer A, Ziyyat A, Karim A, Berraaouan A, Seddik R, Mekhfi H. Antithrombotic activity of Punica granatum, L (Pomegranate): Experimental investigation and exploration of its mechanism of action on primary and secondary hemostasis in vitro and ex vivo. Journal of Molecular Structure. 2025;1321:140195 [Crossref]
4- Ouadghiri Z, Guedmioui A, El Faqer O, Benchama Z, El Ouaddari A, Rais S, El Amrani A, Mtairag E. Comparative HPLC-Based Phytochemical Profiling, Antioxidant and Antibacterial Activities, and Multivariate PCA Analysis of Aqueous and Ethanolic Extracts of Moroccan Dysphania ambrosioides. Food Chemistry Advances. 2026;:101356 [Crossref]
5- Mahmoud M, Alsayegh A, Kambal N, Alsaeedi A, Mozaffar B, Mohammed E, Alwadani A, Hafiz H. Comparative evaluation of antioxidant, cytoprotective, and anti-arthritic activities of pomegranate peel powder and coarse powdered date seeds: implications for functional nutrition. Journal of Genetic Engineering and Biotechnology. 2026;24(2):100696 [Crossref]
6- Lima Bezerra J, Domingos da Silva J. Dental applications of Punica granatum L. in the treatment of gingivitis: A review of ethnomedicinal uses, randomized clinical trials, and antibacterial potential against Porphyromonas gingivalis. Journal of Ethnopharmacology. 2025;336:118701 [Crossref]
7- El Faqer O, Elkoraichi I, Latif M, Debierre-Grockiego F, Ouadghiri Z, Rais S, Dimier-Poisson I, Mtairag E. Pharmacological insights into Laurus nobilis: HPLC profiling and evaluation of its anti-Toxoplasma, antioxidant, and anti-hemolytic properties. Biochemical Systematics and Ecology. 2024;117:104891 [Crossref]
8- El Faqer O, Ouadghiri Z, Wahnou H, Elkoraichi I, El Faqer A, Mazti A, Rais S, Mtairag E. Dual anti-inflammatory and immunomodulatory effects of clove essential oil and eugenol: targeting neutrophil functions and experimental arthritis. Inflammopharmacol. 2026;34(1):763 [Crossref]
9- Zemmouli N, Ramdane F, Guezzoun N. Exploring the Antioxidant, Anti-Inflammatory, and Antibacterial Properties of Green-Synthesized ZnO Nanoparticles Using Juniperusphoenicea L.. Chemistry Africa. 2025;8(3):935 [Crossref]
10- Mounia L, Ismail E, Othman E, Hicham W, Rajaa E, El Mostafa M, Mounia O, Samira R. Aframomum Melegueta: Evaluation of Chronic Toxicity, HPLC Profiling, and In Vitro/In Vivo Antioxidant Assessment of Seeds Extracts. Chemistry & Biodiversity. 2025;22(1) [Crossref]

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