Chemical composition of essential oils of Citrus limon peel from three Moroccan regions and their antioxidant, anti-inflammatory, antidiabetic and dermatoprotective properties

Meriam El Aboubi ¹ , Douae Ben Hdech ² , Samir Bikri ³ * , Asmae Benayad ³ , Anouar El Magri ⁴ , Youssef Aboussaleh ³ , El Mahjoub Aouane ¹

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1- Lukman H, Adedirin O, Sabiu S. Antidiabetic potential of citrus essential oil nanoparticles: A systematic review of current evidence and future directions. Journal of Essential Oil Bearing Plants. 2025;:1 [Crossref]

2- Stavrakakis I, Melidis P, Kavroulakis N, Goliomytis M, Simitzis P, Ntougias S. Bioeconomy-Based Approaches for the Microbial Valorization of Citrus Processing Waste. Microorganisms. 2025;13(8):1891 [Crossref]

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4- Munir H, Yaqoob S, Awan K, Imtiaz A, Naveed H, Ahmad N, Naeem M, Sultan W, Ma Y. Unveiling the Chemistry of Citrus Peel: Insights into Nutraceutical Potential and Therapeutic Applications. Foods. 2024;13(11):1681 [Crossref]

5- El Hachlafi N, Elbouzidi A, Batbat A, Taibi M, Jeddi M, Addi M, Naceiri Mrabti H, Fikri-Benbrahim K. Chemical Composition and Assessment of the Anti-Inflammatory, Antioxidant, Cytotoxic and Skin Enzyme Inhibitory Activities of Citrus sinensis (L.) Osbeck Essential Oil and Its Major Compound Limonene. Pharmaceuticals. 2024;17(12):1652 [Crossref]

6- Santhanakrishnan V, Pallavi H, Dwaraka V, Navinraj S, Vellaikumar S, Boopathi N, Kumar K. Unravelling the chemical diversity of essential oils in endangered citrus species from Northeast India. ProcIndian Natl Sci Acad. 2025; [Crossref]

7- El Aboubi M, Hmada A, Kharbouch O, Saber I, Safi Z, Hsissou R, Wazzan N, Bikri S, Dkhireche N, Aouane E. Theoretical and electrochemical investigation of citrus limon peel essential oil as green corrosion inhibitor for mild steel in 1 M HCl. Next Materials. 2025;9:101259 [Crossref]

8- Gölükcü M, Bozova B, Tokgöz H, Turgut D, Çınar O, Turgutoglu E, Giuffrè A. Effects of cultivar, harvesting time and isolation techniques on the essential oil compositions of some lemon cultivars. AIMSAGRI. 2024;9(3):904 [Crossref]

9- Kumari P, Barbhuiya P, Pathak M. Therapeutic Potential of Citrus Species Against Metabolic Syndrome: Insights from Preclinical and Clinical Studies. Curr Nutr Rep. 2025;14(1) [Crossref]

10- Asmae E, Meriam E, Samir B, Youssef A, Bour A. Mitigating Hyperglycemia-Induced learning and memory impairment: Insulin Combined with Lemon Peel Essential Oil effects on Hippocampal Oxidative Stress, Neuroinflammation, and BDNF Expression in Type 1 Diabetic Rats. RJPT. 2025;:2537 [Crossref]

11- Aboubi M E, S B, A H, N B, M A. The protective effect of Lemon Peel Essential Oil on Pancreas and Brain Oxidative Stress and Inflammation induced by Streptozotocin-Nicotinamide in rats: Behavioral and Biochemical Evidences. RJPT. 2023;:4897 [Crossref]

12- Karungamye P, Shaib S, Mazengo G, Ndege S. The Influence of Extraction Method on the Composition of Essential Oils from Lemon Peels Analysed with FTIR. MJRD. 2025;6(3):388 [Crossref]

13- Kehal F, Chemache L, Himed L, Barkat M. Antimicrobial and Antioxidant Activities of Citrus limon Peel Essential Oils and their Application as a Natural Preservative in Fresh Cream: Effects on Oxidative and Sensory Properties. 2023;27(1):1 [Crossref]

14- Budiarto R, Khalisha A, Sari D, Ujilestari T, Wahyono T, Azmi A, Adli D, Lusiana E, Sitaresmi P, Sholikin M. Antioxidant properties of lemon essential oils: a meta-analysis of plant parts, extraction methods, dominant compounds, and antioxidant assay categories. Chem Biol Technol Agric. 2024;11(1) [Crossref]

15- Bhattacharyya S, Sarma S, Dutta P, Begum T, Lal M, Perveen K, Bukhari N. Insights into Citrus limon (L.) Osbeck peel essential oil from NE India: A study of its pharmacological properties and chemical composition . Journal of Essential Oil Bearing Plants. 2024;27(5):1362 [Crossref]

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