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J Herbmed Pharmacol. 2023;12(2): 283-298. doi: 10.34172/jhp.2023.31

Original Article

In vitro and in silico investigation of garlic’s (Allium sativum) bioactivity against 15-lipoxygenase mediated inflammopathies

Arman Mahmud Khan 1 ORCID, Md. Arman Sharif 1 ORCID, Rahagir Salekeen 1 ORCID, Md. Hafijur Rahman 1 ORCID, Sakib Mahmud 1 ORCID, Partha Biswas 2 ORCID, Md. Nazmul Hasan 2 ORCID, Kazi Mohammed Didarul Islam 1 ORCID, Md. Morsaline Billah 1 ORCID, Md. Emdadul Islam 1 * ORCID

Cited by CrossRef: 4

1- Dutta A, Hossain M, Somadder P, Moli M, Ahmed K, Rahman M, Bui F. Exploring the therapeutic targets of stevioside in management of type 2 diabetes by network pharmacology and in-silico approach. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2024;18(8):103111 [Crossref]
2- Aliabadi A, Khanniri E, Mahboubi-Rabbani M, Bayanati M. Dual COX-2/15-LOX inhibitors: A new avenue in the prevention of cancer. European Journal of Medicinal Chemistry. 2023;261:115866 [Crossref]
3- Nur Kabidul Azam M, Biswas P, Mohaimenul Islam Tareq M, Ridoy Hossain M, Bibi S, Anisul Hoque M, khandker A, Ashraful Alam M, Nazmul Hasan Zilani M, Shahedur Rahman M, Albekairi N, Alshammari A, Nazmul Hasan M. Identification of antidiabetic inhibitors from Allophylus villosus and Mycetia sinensis by targeting α-glucosidase and PPAR-γ: In-vitro, in-vivo, and computational evidence. Saudi Pharmaceutical Journal. 2024;32(1):101884 [Crossref]
4- Azam M, Biswas P, Khandker A, Tareq M, Tauhida S, Shishir T, Bibi S, Alam M, Zilani M, Albekairi N, Alshammari A, Rahman M, Hasan M. Profiling of antioxidant properties and identification of potential analgesic inhibitory activities of Allophylus villosus and Mycetia sinensis employing in vivo, in vitro, and computational techniques. Journal of Ethnopharmacology. 2025;336:118695 [Crossref]
5- Sharif M, Khan A, Salekeen R, Rahman M, Mahmud S, Bibi S, Biswas P, Nazmul Hasan M, Islam K, Rahman S, Islam M, Alshammari A, Alharbi M, Hayee A. Phyllanthus emblica (Amla) methanolic extract regulates multiple checkpoints in 15-lipoxygenase mediated inflammopathies: Computational simulation and in vitro evidence. Saudi Pharmaceutical Journal. 2023;31(8):101681 [Crossref]
6- Chimplee S, Sama-ae I, Sangkanu S, Mitsuwan W, Chuprom J, Boonhok R, Khan D, Biswas P, Hasan M, Tabo H, Salibay C, Wilairatana P, Pereira M, Nawaz M, Bodade R, Sundar S, Paul A, Nissapatorn V. Anti-adherent effects of Rhizophora apiculata bark and leaf extracts and computational prediction of the effects of its compound on β-tubulin interaction in Acanthamoeba triangularis genotype 4. Vet World. 2024;:2829 [Crossref]
7- Saha S, Biswas P, Tareq M, Rahman Sakib M, Akter Rakhi S, Zilani M, Harrath A, Rahman M, Hasan M. Pharmacoinformatics, Molecular Dynamics Simulation, and Quantum Mechanics Calculation Based Phytochemical Screening of Croton bonplandianum Against Breast Cancer by Targeting Estrogen Receptor-α (ERα). Applied Sciences. 2024;14(21):9878 [Crossref]
8- Devnath H, Biswas P, Oisay D, Medha M, Islam M, Biswas B, Hossain A, Hasan M, Ahmed K, Hossain H, Sadhu S. Bioactive phytocompounds profiling and the evaluation of analgesic, anti-inflammatory, and antihyperglycemic potential of Argyreia capitiformis (Poir.) Ooststr.: A combined n vitro, n vivo, and computational investigations. Journal of Ethnopharmacology. 2025;337:118949 [Crossref]
9- Islam M, Hossain M, Hasnat S, Shuvo M, Akter S, Maria M, Tahcin A, Hossain M, Hoque M. In-silico study unveils potential phytocompounds in Andrographis paniculata against E6 protein of the high-risk HPV-16 subtype for cervical cancer therapy. Sci Rep. 2024;14(1) [Crossref]
10- Nahar N, Nazmul Hasan Zilani M, Biswas P, Morsaline Billah M, Bibi S, Albekairi N, Alshammari A, Nazmul Hasan M. Profiling of secondary metabolite and evaluation of anti-diabetic potency of Crotalaria quinquefolia (L): In-vitro, in-vivo, and in-silico approaches. Saudi Pharmaceutical Journal. 2024;32(1):101887 [Crossref]