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J Herbmed Pharmacol. 2021;10(4): 443-458. doi: 10.34172/jhp.2021.52

Original Article

Two new flavonoids and anticancer activity of Hymenosporum flavum: in vitro and molecular docking studies

Rehab Fikry Taher 1 * ORCID, Ahmed A. Al-Karmalawy 2 ORCID, Ahmed I. Abd El Maksoud 3 ORCID, Hany Khalil 4 ORCID, Amr Hassan 5 ORCID, Ezzel-Din A. El-Khrisy 1 ORCID, Walaa El-Kashak 1 ORCID

Cited by CrossRef: 47


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21- Zakaria M, Sharaky M, Noreddin A, Alnajjar R, EL-Shesheny R, Kutkat O, El‐Beeh M, Abourehab M, Al-Karmalawy A. Investigating the superiority of chitosan/D-alpha-tocopheryl polyethylene glycol succinate binary coated bilosomes in promoting the cellular uptake and anti-SARS-CoV-2 activity of polyphenolic herbal drug candidate. International Journal of Pharmaceutics. 2023;646:123385 [Crossref]
22- Alalem M, Dabous E, Awad A, Alalem N, Guirgis A, El-Masry S, Khalil H. Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication. Virol J. 2023;20(1) [Crossref]
23- Chfat H, Radhi A, Radhi A, Alrubaie I. Design, synthesis, In Silico and in vitro studies urea derivatives as VEGFR-2 inhibitors. Journal of Molecular Structure. 2025;1343:142863 [Crossref]
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25- Elagawany M, Elmaaty A, Mostafa A, Abo Shama N, Santali E, Elgendy B, Al-Karmalawy A. Ligand-based design, synthesis, computational insights, and in vitro studies of novel N -(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease . Journal of Enzyme Inhibition and Medicinal Chemistry. 2022;37(1):2112 [Crossref]
26- El-Naggar A, Hassan A, Elkaeed E, Alesawy M, Al‐Karmalawy A. Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR and VEGFR-2. Bioorganic Chemistry. 2022;123:105770 [Crossref]
27- Veeramuthu K, Ahuja V, Annadurai P, Gideon D, Sundarrajan B, Rusu M, Annadurai V, Dhandayuthapani K. Chemical Profiling and Biological Activity of Psydrax dicoccos Gaertn. Molecules. 2023;28(20):7101 [Crossref]
28- Diab R, Abdel-Sami Z, Abdel-Aal E, Al-Karmalawy A, Abo-Dya N. Design and synthesis of a new series of 3,5-disubstituted-1,2,4-oxadiazoles as potential colchicine binding site inhibitors: antiproliferative activity, molecular docking, and SAR studies. New J Chem. 2021;45(46):21657 [Crossref]
29- Alalem N, Alalem M, Awad A, Elshamy A, Elalem O, Tabl A, Ebaid M, Khalil H. A novel mechanistic study on inhibiting influenza A virus replication by a newly extracted polypeptide targeting host autophagy. Arch Microbiol. 2025;207(11) [Crossref]
30- Abo Elmaaty A, Al‐Karmalawy A, Nafie M, Shamaa M, Zaki I, Alnajjar R, Zakaria M. Experimental design of D-α-tocopherol polyethylene glycol 1000 succinate stabilized bile salt based Nano-vesicles for improved cytotoxicity and bioavailability of colchicine binding site inhibitor Candidates: In Vitro, in silico, and pharmacokinetic studies. International Journal of Pharmaceutics. 2023;640:122980 [Crossref]
31- Chauhan P, Pandey P, Ramniwas S, Verma M, Ganeshan S, Rajotiya S, Devi S, Lakhanpal S, Kumar M, Pandey S, Khan F. Unveiling the Anticancer Potential of Phytocompounds: Pioneering Future Cancer Therapies. CTMC. 2025;25(20):2417 [Crossref]
32- Abo Elmaaty A, Eldehna W, Khattab M, Kutkat O, Alnajjar R, El-Taweel A, Al-Rashood S, Abourehab M, Binjubair F, Saleh M, Belal A, Al-Karmalawy A. Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies. IJMS. 2022;23(20):12235 [Crossref]
33- Al-Karmalawy A, Mousa M, Sharaky M, Mourad M, El-Dessouki A, Hamouda A, Alnajjar R, Ayed A, Shaldam M, Tawfik H. Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments. J Med Chem. 2024;67(1):492 [Crossref]
34- Elebeedy D, Badawy I, Elmaaty A, Saleh M, Kandeil A, Ghanem A, Kutkat O, Alnajjar R, Abd El Maksoud A, Al-karmalawy A. In vitro and computational insights revealing the potential inhibitory effect of Tanshinone IIA against influenza A virus. Computers in Biology and Medicine. 2022;141:105149 [Crossref]
35- Elmaaty A, Darwish K, Chrouda A, Boseila A, Tantawy M, Elhady S, Shaik A, Mustafa M, Al-karmalawy A. In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity. ACS Omega. 2022;7(1):875 [Crossref]
36- Ibrahim R, Abdel-Baki P, Mohamed O, Al-Karmalawy A, Tripathi A, El-Shiekh R. Metabolites profiling, in-vitro and molecular docking studies of five legume seeds for Alzheimer’s disease. Sci Rep. 2024;14(1) [Crossref]
37- Fekry T, Salem M, Abd-Elaziz A, Muawia S, Naguib Y, Khalil H. Anticancer Properties of Selenium-Enriched Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), in Colon Cancer In Vitro . Int J Med Mushrooms. 2022;24(11):1 [Crossref]
38- Al-Karmalawy A, Alnajjar R, Elmaaty A, Binjubair F, Al-Rashood S, Mansour B, Elkamhawy A, Eldehna W, Mansour K. Investigating the promising SARS-CoV-2 main protease inhibitory activity of secoiridoids isolated from Jasminum humile ; in silico and in Vitro assessments with structure-activity relationship . Journal of Biomolecular Structure and Dynamics. 2024;42(13):6941 [Crossref]
39- Hamed A, El-Shiekh R, Mohamed O, Aboutabl E, Fathy F, Fawzy G, Al-Taweel A, Elsayed T, Tripathi A, Al-Karmalawy A. Cholinesterase Inhibitors from an Endophytic Fungus Aspergillus niveus Fv-er401: Metabolomics, Isolation and Molecular Docking. Molecules. 2023;28(6):2559 [Crossref]
40- Raghunath Khedkar N, Sindkhedkar M, Joseph A. Computational Design, Synthesis, and Bioevaluation of 2-(Pyrimidin-4-yl)oxazole-4-carboxamide Derivatives: Dual Inhibition of EGFRWT and EGFRT790M with ADMET Profiling. Bioorganic Chemistry. 2024;143:107027 [Crossref]
41- Shahin I, Mohamed K, Taher A, Elsebaei M, Mayhoub A, Kassab A, Elshewy A. New Phenylthiazoles: Design, Synthesis, and Biological Evaluation as Antibacterial, Antifungal, and Anti‐COVID‐19 Candidates. Chemistry & Biodiversity. 2023;20(11) [Crossref]
42- Rana J, Gul K, Mumtaz S. Isorhamnetin: Reviewing Recent Developments in Anticancer Mechanisms and Nanoformulation-Driven Delivery. IJMS. 2025;26(15):7381 [Crossref]
43- Salem M, Mohamed O, Mosalam E, Elberri A, Abdel-Bar H, Hassan M, Al-Karmalawy A, Tripathi A, Ezzat S, Abo Mansour H. Investigation of the phytochemical composition, antioxidant, antibacterial, anti-osteoarthritis, and wound healing activities of selected vegetable waste. Sci Rep. 2023;13(1) [Crossref]
44- Gaber A, Sharaky M, Elmaaty A, Hammouda M, Mourad A, Elkhawaga S, Mokhtar M, Abouzied A, Mourad M, Al-Karmalawy A. Design and Synthesis of Novel Pyrazolopyrimidine Candidates As Promising EGFR-T790M Inhibitors and Apoptosis Inducers. Future Med Chem. 2023;15(19):1773 [Crossref]
45- Shalaby A, Eid H, El-Shiekh R, Mohamed O, Tripathi A, Al-Karmalawy A, Sleem A, Morsy F, Ibrahim K, Tadros S, Youssef F. Taming Food–Drug Interaction Risk: Potential Inhibitory Effects of Citrus Juices on Cytochrome Liver Enzymes Can Safeguard the Liver from Overdose Paracetamol-Induced Hepatotoxicity. ACS Omega. 2023;8(29):26444 [Crossref]
46- Madbouly E, Lashine E, Al-Karmalawy A, Sebaiy M, Pratsinis H, Kletsas D, Metwally K. Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1:in vitro, molecular docking, and SAR studies. New J Chem. 2022;46(46):22013 [Crossref]
47- Khantal A, Bais N. Hepatoprotective Activity of Vitex Negundo and Hygrophila auriculata Extracts in combination. ijnrph. 2024;:73 [Crossref]
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49- Shalaby A, Eid H, El‐Shiekh R, Youssef F, Al‐Karmalawy A, Farag N, Sleem A, Morsy F, Ibrahim K, Tadros S. A Comparative GC/MS Analysis of Citrus Essential Oils: Unveiling the Potential Benefits of Herb‐Drug Interactions in Preventing Paracetamol‐Induced Hepatotoxicity. Chemistry & Biodiversity. 2023;20(9) [Crossref]
50- Al-Warhi T, Al-Karmalawy A, Elmaaty A, Alshubramy M, Abdel-Motaal M, Majrashi T, Asem M, Nabil A, Eldehna W, Sharaky M. Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR WT and EGFR T790M inhibitors . Journal of Enzyme Inhibition and Medicinal Chemistry. 2023;38(1):176 [Crossref]