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J Herbmed Pharmacol. 2019;8(2): 126-132. doi: 10.15171/jhp.2019.20

Original Article

Anti-inflammatory and analgesic activity of ointment based on dense ginger extract (Zingiber officinale)

Iryna Kravchenko 1, 2 ORCID, Lidiya Eberle 1, Mariia Nesterkina 1, 2 * ORCID, Alona Kobernik 1

Cited by CrossRef: 19

1- Cheshfar F, Bani S, Mirghafourvand M, Hasanpour S, Javadzadeh Y. The Effects of Ginger (Zingiber officinale) Extract Ointment on Pain and Episiotomy Wound Healing in Nulliparous Women: A Randomized Clinical Trial. J Caring Sci. 2023;12(3):181 [Crossref]
2- Lefrioui Y, Chebaibi M, Bichara M, Mssillou I, Bekkari H, Giesy J, Bousta D. Ethnobotanical survey of medicinal plants used in north-central Morocco as natural analgesic and anti-inflammatory agents. Scientific African. 2024;25:e02275 [Crossref]
3- Aleksandrova A, Nesterkina M, Gvozdii S, Kravchenko I. Phytochemical analysis and anti-inflammatory activity of Cladophora aegagropila extract. J Herbmed Pharmacol. 2020;9(1):81 [Crossref]
4- Ballester P, Cerdá B, Arcusa R, Marhuenda J, Yamedjeu K, Zafrilla P. Effect of Ginger on Inflammatory Diseases. Molecules. 2022;27(21):7223 [Crossref]
5- SARAÇ H, DEMİRBAŞ A, TÜZÜN B. Could Zingiber officinale plant be effective against Omicron BA.2.75 of SARS-CoV-2?. 2023;7(3):42 [Crossref]
6- Pakale D, Khanwelkar C, Thorat V, Jadhav S, Tiwari D. Study of the Analgesic Activity of the Aqueous and Methanolic Extracts of Fresh Rhizome of Zingiber officinale in Wistar Rats. 2024; [Crossref]
7- Bahmani F, Kazemeini H, Hoseinzadeh-Chahkandak F, Farkhondeh T, sedaghat M. Sedation with medicinal plants: A review of medicinal plants with sedative properties in Iranian ethnoblotanical documents. Plant Biotechnol Persa. 2019;1(1):13 [Crossref]
8- Gupta M, Singh N, Gulati M, Gupta R, Sudhakar K, Kapoor B. Herbal bioactives in treatment of inflammation: An overview. South African Journal of Botany. 2021;143:205 [Crossref]
9- Saher T, Manzoor R, Abbas K, Mudassir J, Wazir M, Ali E, Ahmed Siddiqui F, Rasul A, Qadir M, Aleem A, Qaiser N, Usman A, Romman M, Ali M. Analgesic and Anti-Inflammatory Properties of Two Hydrogel Formulations Comprising Polyherbal Extract. JPR. 2022;Volume 15:1203 [Crossref]
10- Heidari‐Beni M, Moravejolahkami A, Gorgian P, Askari G, Tarrahi M, Bahreini‐Esfahani N. Herbal formulation “turmeric extract, black pepper, and ginger” versus Naproxen for chronic knee osteoarthritis: A randomized, double‐blind, controlled clinical trial. Phytotherapy Research. 2020;34(8):2067 [Crossref]
11- Nooreen Z, Wal P, Summaiyya F. A Systemic Review on Nutraceutical Supplements used in the Management of Osteoarthritis. RAFNA. 2024;15(1):33 [Crossref]
12- Szymczak J, Grygiel-Górniak B, Cielecka-Piontek J. Zingiber Officinale Roscoe: The Antiarthritic Potential of a Popular Spice—Preclinical and Clinical Evidence. Nutrients. 2024;16(5):741 [Crossref]
13- Samy B, Raman K, Velayutham S, Senthilkumar N, Thirumalaivasan N, Kanagaraj K, Pothu R, Boddula R, Radwan A, Al-Qahtani N. Natural product extract fractions as potential arthritis treatments: A detailed analysis using in-silico, in-vivo, and in-vitro methods. International Immunopharmacology. 2025;144:113595 [Crossref]
14- Nefodov O, Eberle L, Tsisak A, Gritsuk O, Aleksandrova O, Guzenko O, Shkodovska A, Burega I. EVALUATION OF ANTINOCICEPTIVE AND ANTIEXUDATIVE EFFECTS OF A COMPLEX HERBAL PREPARATION IN THE THERAPY OF SOMATIC PAIN AND INFLAMMATION OF DIFFERENT ORIGIN. WOMAB. 2023;19(85):224 [Crossref]
15- Deng M, Yun X, Ren S, Qing Z, Luo F. Plants of the Genus Zingiber: A Review of Their Ethnomedicine, Phytochemistry and Pharmacology. Molecules. 2022;27(9):2826 [Crossref]
16- Alsahli M, Almatroodi S, Almatroudi A, Khan A, Anwar S, Almutary A, Alrumaihi F, Rahmani A, Roscetto E. 6-Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine-Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity. Mediators of Inflammation. 2021;2021:1 [Crossref]
17- Ansaripour S, Dehghan M. Efficacy of some Herbal Medicines in Osteoarthritis with a Focus on Topical Agents: A Systematic Review. CPD. 2020;26(22):2676 [Crossref]
18- Adrianta K, Somantara I. The Curcumin and Gingerol Combination as an Immune Regulator and Anti-Inflammatory Agent of SARS-CoV Infection According to a Nutrigenomic Approach: A Mini-Review. NPJ. 2023;13(1) [Crossref]
19- Kaushik D, Kumar M, Proestos C, Oz F, Gupta P, Kumar A, Kundu P, Kaur J, kumar V, Anjali A, Xiang J. A narrative review on the anti-inflammatory efficacy of Bougainvillea spectabilis Willd. and its various applications. Journal of Agriculture and Food Research. 2023;12:100570 [Crossref]
20- Nesterkina M, Barbalat D, Kravchenko I. Design, synthesis and pharmacological profile of (−)-verbenone hydrazones. 2020;18(1):943 [Crossref]
21- Kim S, Cheon C, Kim B, Kim W. The Effect of Ginger and Its Sub-Components on Pain. Plants. 2022;11(17):2296 [Crossref]
22- Posatska N, Grytsyk A, Struk O. STUDY OF THE ANTI-EXUDATIVE ACTIVITY OF VERBENA OFFICINALIS L. HERB EXTRACTS IN MODELS OF SWELLINGS OF DIFFERENT GENES. Scientific and practical journal. 2024;:137 [Crossref]