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J Herbmed Pharmacol. 2018;7(2): 79-87. doi: 10.15171/jhp.2018.14

Original Article

Analysis of ergosterol and gene expression profiles of sterol Δ5,6-desaturase (ERG3) and lanosterol 14α-demethylase (ERG11) in Candida albicans treated with carvacrol

Fahimeh Alizadeh 1, Alireza Khodavandi 2 * ORCID, Samad Esfandyari 1, Sadegh Nouripour-Sisakht 3

Cited by CrossRef: 15

1- Oktay Başeğmez H, Baydemir Peşint G, Nergiz M, Zenger O. Determination of mold contamination using ergosterol imprinted particles. Biotechnology Progress. 2021;37(1) [Crossref]
2- Ayed A, Essid R, Mankai H, Echmar A, Fares N, Hammami M, Sewald N, Limam F, Tabbene O. Synergistic antifungal activity and potential mechanism of action of a glycolipid-like compound produced by Streptomyces blastmyceticus S108 against Candida clinical isolates. 2023;134(11) [Crossref]
3- Miranda-Cadena K, Marcos-Arias C, Perez-Rodriguez A, Cabello-Beitia I, Mateo E, Sevillano E, Madariaga L, Quindós G, Eraso E. In vitro and in vivo anti-Candida activity of citral in combination with fluconazole. Journal of Oral Microbiology. 2022;14(1) [Crossref]
4- Erfaninia M, Alizadeh F. Killing Kinetics of Carvacrol against Fluconazole-Susceptible and -Resistant Isolates of Candida tropicalis. mljgoums. 2023;17(1):27 [Crossref]
5- Hosseini Bafghi M, Zarrinfar H, Darroudi M, Zargar M, Nazari R. Green synthesis of selenium nanoparticles and evaluate their effect on the expression of ERG3, ERG11 and FKS1 antifungal resistance genes in Candida albicans and Candida glabrata. 2022;74(5):809 [Crossref]
6- Souza R, Dantas A, Melo C, Felício I, Oliveira E. Nanotechnology as a tool to improve the biological activity of carvacrol: A review. Journal of Drug Delivery Science and Technology. 2022;76:103834 [Crossref]
7- Butassi E, Svetaz L, Carpinella M, Efferth T, Zacchino S. Fungal Biofilms as a Valuable Target for the Discovery of Natural Products That Cope with the Resistance of Medically Important Fungi—Latest Findings. Antibiotics. 2021;10(9):1053 [Crossref]
8- Norouzi N, Alizadeh F, Khodavandi A, Jahangiri M. Antifungal activity of menthol alone and in combination on growth inhibition and biofilm formation of Candida albicans. Journal of Herbal Medicine. 2021;29:100495 [Crossref]
9- da Silva Neto J, da Costa H, Vasconcelos I, Pereira M, Oliveira J, Lopes T, Dias L, Araújo N, Moura L, Van Tilburg M, Guedes M, Lopes L, Morais E, de Oliveira Bezerra de Sousa D. Role of membrane sterol and redox system in the anti-candida activity reported for Mo-CBP2, a protein from Moringa oleifera seeds. International Journal of Biological Macromolecules. 2020;143:814 [Crossref]
10- Sasidharan S, Nishanth K, Nair H. A semi purified hydroalcoholic fraction from Caesalpinia bonduc seeds causes ergosterol biosynthesis inhibition in Candida albicans resulting in cell membrane damage. Front Pharmacol. 2023;14 [Crossref]
11- Lim F, Rasid O, Idris A, As'wad A, Vadamalai G, Parveez G, Wong M. Gene silencing of Ganoderma boninense Lanosterol 14α-demethylase (GBERG11) affects ergosterol biosynthesis and pathogenicity towards oil palm. Scientia Horticulturae. 2024;332:113198 [Crossref]
12- Feridoniy M, Alizadeh F, Panahi Kokhdan E, Khodavandi A. Study of the antifungal potential of carvacrol on growth inhibition of Candida krusei in a systemic candidiasis. ADV TRADIT MED (ADTM). 2020;20(4):591 [Crossref]
13- Akermi S, Smaoui S, Chaari M, Elhadef K, Gentile R, Hait M, Roymahapatra G, Mellouli L. Combined in vitro/in silico approaches, molecular dynamics simulations and safety assessment of the multifunctional properties of thymol and carvacrol: A comparative insight. Chemistry & Biodiversity. 2024;21(2) [Crossref]
14- Mani-López E, Cortés-Zavaleta O, López-Malo A. A review of the methods used to determine the target site or the mechanism of action of essential oils and their components against fungi. SN Appl Sci. 2021;3(1) [Crossref]
15- Hosseini S, Alizadeh F, Nouripour-Sisakht S, Khodavandi A. Synergistic interaction of fluconazole/sodium bicarbonate on the inhibition of Candida glabrata phospholipase gene. Braz J Pharm Sci. 2022;58 [Crossref]
16- Zare‐Khafri M, Alizadeh F, Nouripour‐Sisakht S, Khodavandi A, Gerami M. Inhibitory effect of magnetic iron‐oxide nanoparticles on the pattern of expression of lanosterol 14 α ‐demethylase ( ERG11 ) in fluconazole‐resistant colonising isolate of Candida albicans . IET nanobiotechnol. 2020;14(5):375 [Crossref]