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J Herbmed Pharmacol. 2018;7(2): 100-105. doi: 10.15171/jhp.2018.17

Original Article

Antispasmodic activity of apigenin and luteolin, two components of Dracocephalum kotschyi extract, on rat ileum contractions

Hassan Sadraei 1 * ORCID, Mostafa Ghanadian 2, Golamreza Asghari 2, Nastaran Sekhavati 1, 2

Cited by CrossRef: 15

1- Pirvu L, Nita S, Rusu N, Bazdoaca C, Neagu G, Bubueanu C, Udrea M, Udrea R, Enache A. Effects of Laser Irradiation at 488, 514, 532, 552, 660, and 785 nm on the Aqueous Extracts of Plantago lanceolata L.: A Comparison on Chemical Content, Antioxidant Activity and Caco-2 Viability. Applied Sciences. 2022;12(11):5517 [Crossref]
2- Szadkowska D, Chłopecka M, Strawa J, Jakimiuk K, Augustynowicz D, Tomczyk M, Mendel M. Effects of Cirsium palustre Extracts and Their Main Flavonoids on Colon Motility—An Ex Vivo Study. IJMS. 2023;24(24):17283 [Crossref]
3- Basheerudd S, Abdulaziz B, Alanazi A, Almusharra B, Alanazi N, Saad K, Alanazi S, Abduallah K, Alrashid S, Alanazi F, S. Alamri A, F. Alsanie W, Alhomrani M. Evaluation of Skeletal Muscle Relaxant Activity of Apigenin in Animal Experimental Models. International J of Pharmacology. 2021;17(6):400 [Crossref]
4- Sadraei H, Sajjadi S, Asghari G, Khalili M. Effect of Matricaria chamomilla hydro-alcoholic and flavonoids rich extracts on rat isolated uterus. J Herbmed Pharmacol. 2020;9(1):35 [Crossref]
5- Zayed G, Ibrahim M, Alshora D, El-Garhy O, Kamal I, Amin M, Bakr A, Ali F. Novel water-soluble lubricant for the preparation of tiemonium methylsulfate fast-dissolving tablets. Journal of Drug Delivery Science and Technology. 2020;60:102031 [Crossref]
6- da Silva Mendes J, Cunha W, Rodrigues F, Silveira E, de Lima R, da Costa J. Cissampelos genus: biological activities, ethnobotanical and phytochemical aspects. Phytochem Rev. 2020;19(4):955 [Crossref]
7- Sadraei H, Ghanadian S, Asghari G, Gavahian A. Bronchodilator effect of apigenin and luteolin, two components of Dracocephalum kotschyi on isolated rabbit trachea. J Herbmed Pharmacol. 2019;8(4):281 [Crossref]
8- Sadraei H, Rasouli-Amirabadi A, Yekdaneh A, Tavakoli N. Bioassay standardization of drug dosage form prepared from hydroalcoholic extract of Dracocephalum kotschyi . J Herbmed Pharmacol. 2022;11(3):435 [Crossref]
9- Karim A, Malek S, Marghich M, Amrani O, Addous A, Beyi L, Aziz M. Antidiarrheal and antispasmodic effects of methanol fraction of Ammodaucus leucotrichus in gastrointestinal problems: an integrative medicine approach. J Smooth Muscle Res. 2024;60(0):39 [Crossref]
10- Minaiyan M, Sadraei H, Yousefi I, Sajjadi S, Talebi A. Evaluation of the effect of hydroalcoholic and flavonoid-enriched extracts of Dracocephalum kotschyi on indomethacin-induced gastric ulcer in rats. 2021;16(2):141 [Crossref]
11- Kaur L, Malhi D, Cooper R, Kaur M, Sohal H, Mutreja V, Sharma A. Comprehensive review on ethnobotanical uses, phytochemistry, biological potential and toxicology of Parthenium hysterophorus L.: A journey from noxious weed to a therapeutic medicinal plant. Journal of Ethnopharmacology. 2021;281:114525 [Crossref]
12- Sadraei H, Khakboo M, Asghari G. Spasmolytic effect of Lonicera japonica extracts on isolated uterus smooth muscle contractions. J Herbmed Pharmacol. 2021;10(3):351 [Crossref]
13- Sadraei H, Sajjadi S, Tarafdar A. Antispasmodic effect of hydroalcoholic and flavonoids extracts ofDracocephalum kotschyion rabbit bladder. J Herbmed Pharmacol. 2020;9(2):145 [Crossref]
14- Lahlou R, Samba N, Soeiro P, Alves G, Gonçalves A, Silva L, Silvestre S, Rodilla J, Ismael M. Thymus hirtus Willd. ssp. algeriensis Boiss. and Reut: A Comprehensive Review on Phytochemistry, Bioactivities, and Health-Enhancing Effects. Foods. 2022;11(20):3195 [Crossref]
15- Randjelović M, Branković S, Jovanović M, Kitić N, Živanović S, Mihajilov-Krstev T, Miladinović B, Milutinović M, Kitić D. An In Vitro and In Silico Characterization of Salvia sclarea L. Methanolic Extracts as Spasmolytic Agents. Pharmaceutics. 2023;15(5):1376 [Crossref]
16- Randjelović M, Branković S, Miladinović B, Milutinović M, Živanović S, Mihajilov-Krstev T, Kitić D. The benefits of Salvia sclarea L. ethanolic extracts on gastrointestinal and respiratory spasms. South African Journal of Botany. 2022;150:621 [Crossref]
17- de Melo I, de Souza I, Vasconcelos L, Scotti M, da Silva B, Schripsema J, Fonseca A, Oliveira E. Metabolomic fingerprinting of Cissampelos sympodialis Eichler leaf extract and correlation with its spasmolytic activity. Journal of Ethnopharmacology. 2020;253:112678 [Crossref]