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J Herbmed Pharmacol. 2025;14(4): 459-468.
doi: 10.34172/jhp.2025.53031
  Abstract View: 25
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Original Article

Diuretic activity of the aqueous leaf extract of Commelina benghalensis Linn. in rats

Kakesse Maguirgue 1*, Bibi-Farouck Aboubakar Oumarou 2* ORCID logo, Adjia Hamadjida 3,4* ORCID logo, Jacques-Brice Oksom 1, David Miaffo 5 ORCID logo, Otchom Boy Brahim 1 ORCID logo, Fidele Ntchapda 6 ORCID logo

1 Department of Life and Earth Sciences, Faculty of Science and Technics, University of Sarh, Sarh, P.O Box 105, Chad
2 Department of Physiological Sciences and Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Garoua, P.O Box 317, Garoua, Cameroon
3 Department of Life Science, Higher Teachers’ Training College, University of Bertoua, P.O Box 652, Bertoua, Cameroon
4 Pharmacological Research Laboratory of Medicinal Plants, Higher Teachers’ Training College, University of Bertoua, Bertoua, P.O Box 652, Bertoua, Cameroon
5 Department of Life and Earth Sciences, Higher Teachers’ Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon
6 Department of Biological Sciences, Faculty of Science, University of Ngaoundere, P.O. Box 454, Ngaoundere, Cameroon
*Corresponding Authors: Kakesse Maguirgue, Email: Kakessemaguirgue@gmail.com; Bibi-Farouck Aboubakar Oumarou, Email: bibifarouck@yahoo.fr; Adjia Hamadjida, Email: hamadjia@gmail.com

Abstract

Introduction: Commelina benghalensis L., referred to as Benghal dayflower, is used in traditional Chinese medicine for its diuretic, antipyretic, and anti-inflammatory properties. The current study was conducted to evaluate the diuretic activity of C. benghalensis extract in rats.

Methods: Thirty-six Wistar rats were randomly assigned to sis equal groups. C. benghalensis extract was administrated to groups 1 to 3 at different doses, conventional diuretics, amiloride and furosemide, to groups 4 and 5, respectively, and distilled water to rats in group 6. The urine volume of each rat was measured at 6, 12, and 24 hours after drug administration, and the total urine volume was calculated. After euthanasia of the animals, the plasma and urine samples were used to measure diuretic activity and to perform biochemical analyses.

Results: The phytochemical examination of C. benghalensis’ aqueous leaf extract revealed phenolics, anthraquinones, flavonoids, and glycosides. The extract promoted diuretic activity in a dose-dependent manner in both female and male rats, comparable to furosemide. Moreover, the extract preserved potassium excretion while increasing sodium excretion, and neither albumin nor glucose was detected in the urine of any of the animals.

Conclusion: The findings indicate that the aqueous leaf extract of C. Benghalensis may serve as a promising diuretic agent, corroborating the historic application of this medicinal herb in managing hypertension.


Implication for health policy/practice/research/medical education:

The results of this study provide scientific evidence to understand the diuretic activity of C. benghalensis in the management of hypertension. Further research is needed to isolate the bioactive compounds and elucidate the underlying mechanisms.

Please cite this paper as: Maguirgue K, Oumarou BFA, Hamadjida A, Oksom JB, Miaffo D, Boy Brahim O, et al. Diuretic activity of the aqueous leaf extract of Commelina benghalensis Linn. in rats. J Herbmed Pharmacol. 2025;14(4):459-468. doi: 10.34172/jhp.2025.53031.

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Submitted: 20 Mar 2025
Revision: 21 Jun 2025
Accepted: 15 Jul 2025
ePublished: 01 Oct 2025
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