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J Herbmed Pharmacol. 2025;14(2): 153-162.
doi: 10.34172/jhp.2025.52822
  Abstract View: 12
  PDF Download: 15

Review

Nano-hydrogel systems in herbal medicine: A systematic review

Muhammad Rifqi Fadillah Muslim 1 ORCID logo, Lutfi Chabib 1* ORCID logo, Hasyrul Hamzah 2 ORCID logo

1 Master Program of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia, Yogyakarta, Indonesia
2 Department of Pharmacy, Faculty of Pharmacy, Muhammadiyah University of East Kalimantan, Samarinda, Indonesia
*Corresponding Author: Lutfi Chabib, Email: lutfi.chabib@uii.ac.id

Abstract

Introduction: The growing popularity of herbal medications among the general public can be attributed to the belief that they are safer and have lower adverse drug reactions compared to synthetic treatments. In vitro studies showing the efficacy of herbal treatments may not always be directly applicable in vivo. Furthermore, the drug’s efficiency in the body is limited by its low solubility in water, necessitating bigger doses and longer dosing intervals for maximum effectiveness. As a result, it is critical to improve the efficiency and effectiveness of nanotechnology in the delivery of herbal medication. This study aims to investigate and collect scientific reports on the characteristics, increased activity and solubility, drug loading, drug release, and nanotoxicity of nano-hydrogel-containing herbal medicines.

Methods: This review used a literature search of the Google Scholar, PubMed, and ScienceDirect databases from January 2024 to July 2024 using the keywords “nano-hydrogel” and “herbal” and “enhance solubility” and “enhance the antibacterial, antioxidant, wound healing activity”.

Results: The literature findings showed that nano-hydrogel was highly effective for the internal and external delivery of medications. The decreased surface-to-volume ratio of nano-hydrogels resulted in a higher efficacy in transporting herbal active compounds across human cell membranes.

Conclusion: Nano-hydrogel is an effective formulation when mixed with herbal active ingredients and might be used for drug production.


Implication for health policy/practice/research/medical education:

Nano-hydrogel is an effective formulation when mixed with herbal active ingredients. It can improve the activity and solubility of herbal active ingredients and might be used for drug production in the future.

Please cite this paper as: Muslim MRF, Chabib L, Hamzah H. Nano-hydrogel systems in herbal medicine: A systematic review. J Herbmed Pharmacol. 2025;14(2):153-162. doi: 10.34172/jhp.2025.52822.

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Submitted: 14 Nov 2024
Revision: 29 Jan 2025
Accepted: 31 Jan 2025
ePublished: 01 Apr 2025
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