Logo-jhp
J Herbmed Pharmacol. 2024;13(2): 324-332.
doi: 10.34172/jhp.2024.49412

Scopus ID: 85192260514
  Abstract View: 189
  PDF Download: 131

Original Article

Phytochemistry and antimicrobial activity of Moroccan Origanum compactum and Ruta montana essential oils against nosocomial bacteria

Rachid Flouchi 1,2 ORCID logo, Marwa Chraibi 1 ORCID logo, Abderrahim Elmniai 3,4 ORCID logo, Karim Fahsi 5 ORCID logo, Ibrahim Touzani 1,2 ORCID logo, Abdellah Farah 6 ORCID logo, Kawtar Fikri-Benbrahim 1* ORCID logo

1 Laboratory of Microbial Biotechnology and Bioactive Molecules, Science and Technologies Faculty, Sidi Mohamed Ben Abdellah University, Fez, Morocco
2 High Institute of Nursing Professions and Health Techniques Annex Taza, Fez, Morocco
3 Human Pathology, Biomedicine and Environment Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco
4 Provincial Laboratory of Epidemiology and Environmental Hygiene, DMS, Taza, Morocco
5 High Institute of Nursing Professions and Health Techniques, Rabat, Morocco
6 Laboratory of Applied Organic Chemistry, Faculty of Sciences and Technology Saïss, Sidi Mohamed Ben Abdallah University, Fez, Morocco
*Corresponding Author: Kawtar Fikri-Benbrahim, Email: kawtar.fikribenbrahim@usmba.ac.ma

Abstract

Introduction: Healthcare-associated infections are a global public health issue with farreaching individual and economic repercussions. The microorganism’s multi-resistance frequently increases the risk that can be lowered by using biomolecules of medicinal plant essential oils (EOs). This study investigated the phytochemical components and antimicrobial potential of the EOs of Moroccan Origanum compactum and Ruta montana gathered from Taza Region.

Methods: The EOs’ chemical analysis was performed by GC/MS and their antimicrobial effects were assessed by the microplate dilution method against eight nosocomial resistantbacterial strains.

Results: The main constituents of O. compactum EO were Thymol (29.56%), carvacrol (26.44%), γ-terpinene (18.86%) and p-cymene (12.01%), while those of R. montana EO were 2-undecanone (85.76%), 2-nonanone (3.95%), 2-decanone (3.67%) and 2-dodecanone (1.94%). The O. compactum EO had important antimicrobial effects on all bacteria experienced. The lower minimum inhibitory concentration (MIC) values were obtained for the tested Staphylococcus species (0.062%, 0.125% (v/v)) while the highest one (2% (v/v)) was obtained for Klebsiella pneumonia and Pantoea spp. The R. montana EO showed MIC values of 4% (v/v) for Pantoea spp. and 8% (v/v) for the other tested strains except K. pneumonia for which no effect was shown.

Conclusion: Therefore, these EOs, especially the O. compactum one, have an interesting antibacterial potential against nosocomial infections and might be used to develop new antimicrobial agents.


Implication for health policy/practice/research/medical education:

This study devoted on the phytochemistry and activity of Ruta montana and Origanum compactum essential oils. The results demonstrated that these essential oils, rich in active compounds, were powerful on nosocomial bacterial strains. So, they might be useful as natural disinfectants and antimicrobials in hospitals to minimize the risk of nosocomial infections, particularly those caused by multi-resistant bacteria.

Please cite this paper as: Flouchi R, Chraibi M, Elmniai A, Fahsi K, Touzani I, Farah A, Fikri-Benbrahim K. Phytochemistry and antimicrobial activity of Moroccan Origanum compactum and Ruta montana essential oils against nosocomial bacteria. J Herbmed Pharmacol. 2024;13(2):324-332. doi: 10.34172/jhp.2024.49412.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 190

Your browser does not support the canvas element.


PDF Download: 131

Your browser does not support the canvas element.

Submitted: 07 Jan 2024
Accepted: 10 Mar 2024
ePublished: 01 Apr 2024
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)