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J Herbmed Pharmacol. 2024;13(3): 353-365.
doi: 10.34172/jhp.2024.49411
  Abstract View: 1274
  PDF Download: 552

Review

A review of ethnomedicinal uses, phytochemistry, nutritional values, and pharmacological activities of Hylocereus polyrhizus

Md. Mustafiz Chowdhury 1 ORCID logo, Md. Iqbal Sikder 2 ORCID logo, Mohammad Rashedul Islam 1 ORCID logo, Nizum Barua 1 ORCID logo, Sharfin Yeasmin 1 ORCID logo, Taslima Akter Eva 1 ORCID logo, Asraful Islam 1 ORCID logo, Israt Jahan Rasna 3 ORCID logo, Mohammed Kamrul Hossain 1* ORCID logo

1 Department of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh
2 Department of Pharmacy, Southern University, Bangladesh
3 Department of Botany, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh
*Corresponding Author: Mohammed Kamrul Hossain, Email: mkhossain73@yahoo.com, Email: mkhossain19732017@gmail.com

Abstract

Hylocereus polyrhizus (Red dragon) fruit, a Cactaceae plant with traditional and medicinal uses, is found in America and South Asia. These fruits have diversified bioactive components, which make them both therapeutically and nutritionally important. This review focuses on the various aspects of this potential plant. This literature review looked at the nutritional information, botanical description, traditional medical use, nutritional values, medicinal uses, chemical compounds, and pharmacological activities of H. polyrhizus. To evaluate the required resources, Scopus, PubMed, Science Direct, Cochrane electronic databases, and Google Scholar search engines were searched (for example, Hylocereus polyrhizus OR dragon fruit, red pitaya OR pitaya, pharmacological AND phytochemical, nutritional AND ethnomedicinal). Prominent bioactive elements in this plant included phenolic compounds such as α-amyrin (15.87%) and β-amyrin (13.90%). H. polyrhizus also contains antioxidant, cardioprotective, anti-inflammatory, antifungal, antibacterial, hypolipidemic, antiviral, thrombolytic, antiplasmodial, anticancer, hepatoprotective, and antidiabetic activities. Because of its colouring pigments, carbohydrates, proteins, and fat substitution properties, the fruit is commonly used in culinary and grooming. An improved understanding of H. polyrhizus, according to this study, could pave the way for the discovery of new, beneficial chemicals with therapeutic potential.

Implication for health policy/practice/research/medical education:

This vital review on Hylocereus polyrhizus (Red dragon) fruit will provide a promising array for researchers to investigate the potential lead chemical compounds responsible for significant pharmacological activities at the molecular level and for pharmaceutical industries to build new therapeutics.

Please cite this paper as: Chowdhury MM, Sikder MI, Islam MR, Barua N, Yeasmin S, Eva TA, et al. A review of ethnomedicinal uses, phytochemistry, nutritional values, and pharmacological activities of Hylocereus polyrhizus. J Herbmed Pharmacol. 2024;13(3):353-365. doi: 10.34172/jhp.2024.49411.

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Submitted: 28 Dec 2023
Accepted: 10 Apr 2024
ePublished: 27 Jun 2024
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