Logo-jhp
J Herbmed Pharmacol. 2024;13(2): 280-288.
doi: 10.34172/jhp.2024.49352
  Abstract View: 388
  PDF Download: 250

Original Article

Immunomodulatory and anti-inflammatory activities of hydro-ethanolic extract of Securidaca longipedunculata Fresen leaves

Affo Dermane 1,2 ORCID logo, Atsu Kodjo George Kporvie 2* ORCID logo, Kpoyizoun Pascaline Kindji 2 ORCID logo, Kossi Metowogo 2 ORCID logo, Kwashie Eklu-Gadegbeku 2 ORCID logo

1 Laboratory of Chemistry, Faculty of Health Sciences, University of Lomé, 01 BP: 1515, Lomé, Togo
2 Research Unit in Pathophysiology-Bioactive Substances and Safety, Faculty of Sciences, University of Lomé, 01 BP: 1515, Lomé, Togo
*Corresponding Author: Kporvie Atsu Kodjo George, Email: georgekporvie@gmail.com

Abstract

Introduction: The use of Securidaca longipedunculata for solving health problems related to immunological disorders is long-standing. The immunomodulatory activity associated with the anti-inflammatory effect of S. longipedunculata has not yet been elucidated by scientific research. The aim of our study is to show that the leaves of S. longipedunculata can solve problems related to immunodeficiency and inflammation.

Methods: The phytochemical compounds of the plant were carried out by solubility tests. The anti-inflammatory activity of the plant was evaluated by the chicken egg albumin denaturation inhibition, membrane stabilization, and C-reactive protein (CRP) tests. The 2,2-diphenyl1-picrylhydrazyl, total antioxidant capacity, and inhibition of lipoperoxidation tests were performed to evaluate the antioxidant activity of the plant. Immunosuppression was induced in rats by cyclophosphamide. The immunomodulatory activity of S. longipedunculata was studied by blood count. The lactate dehydrogenase (LDH) titration showed the effect of S. longipedunculata on the energy balance.

Results: The extract contained polyphenols, flavonoids, and tannins. The tests of albumin denaturation inhibition, membrane stabilisation, CRP, total antioxidant capacity, and 2,2-diphenyl-1-picrylhydrazyl revealed that the extract had anti-inflammatory and antioxidant effects. The blood count results revealed that the extract non-significantly increased the number of leukocytes except in the case of neutrophils and monocytes at a dose of 400 mg/kg (P<0.05). The extract also restored the energy balance in the rats according to the LDH results.

Conclusion: This study reveals that the hydro-ethanolic extract of S. longipedunculata leaves has potential immunostimulant and anti-inflammatory effects.


Implication for health policy/practice/research/medical education:

The results of this study show that Securidaca longipedunculata leaves have pharmacological properties such as anti-inflammatory, antioxidant, and immunostimulant activities. Hence, Securidaca longipedunculata leaves might be used for drug production against these problems.

Please cite this paper as: Dermane A, Kporvie AKG, Kindji KP, Metowogo K, Eklu-Gadegbeku K. Immunomodulatory and anti-inflammatory activities of hydro-ethanolic extract of Securidaca longipedunculata Fresen leaves. J Herbmed Pharmacol. 2024;13(2):280-288. doi: 10.34172/jhp.2024.49352.

First Name
Last Name
Email Address
Comments
Security code


Abstract View: 389

Your browser does not support the canvas element.


PDF Download: 250

Your browser does not support the canvas element.

Submitted: 10 Nov 2023
Accepted: 05 Feb 2024
ePublished: 01 Apr 2024
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)