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J Herbmed Pharmacol. 2024;13(3): 420-426.
doi: 10.34172/jhp.2024.48156
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Original Article

Diuretic activity and urinary electrolyte effects of Hemidesmus indicus (L.) R.Br. & Decalepis hamiltonii Wight & Arn. in experimental rats

Sujith Thatipelli 1,2 ORCID logo, Ganesan Rethinam 3 ORCID logo, Gaddam Dayanand Reddy 4 ORCID logo, Shakila Ramachandran 1* ORCID logo, Gopinath Pushparathinam 2* ORCID logo

1 Department of Chemistry, Siddha Central Research Institute (Central Council for Research in Siddha, Ministry of AYUSH, Government of India), Anna Hospital Campus, Arumbakkam, Chennai-600106, Tamil Nadu, India
2 Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Chennai-603203, Tamil Nadu, , India
3 Department of Biochemistry, Siddha Central Research Institute (Central Council for Research in Siddha, Ministry of AYUSH, Government of India), Anna Hospital Campus, Arumbakkam, Chennai-600106, Tamil Nadu, India
4 Department of Pharmacology, Siddha Central Research Institute (Central Council for Research in Siddha, Ministry of AYUSH, Government of India), Anna Hospital Campus, Arumbakkam, Chennai-600106, Tamil Nadu, India
*Corresponding Authors: Shakila Ramachandran, Email: r.shakila@gov.in; Gopinath Pushparathinam, Email: gopinath.p@ktr.srmuniv.ac.in

Abstract

Introduction: Diuretic drugs are commonly prescribed as primary or adjuvant therapy in various diseases, including congestive cardiac failure and hypertension. However, the adverse effects limit their usage to specific populations. There is an excellent opportunity for drugs with effective diuretic action and limited side effects. The present research was designed to assess the diuretic potential of ethanolic extract of Hemidesmus indicus (HIEE) and Decalepis hamiltonii (DHEE).

Methods: A total of 8 groups (n=6) of Wistar rats were used in the study to assess the diuretic activity of HIEE and DHEE. Group I was treated with 0.5% carboxymethyl cellulose (CMC), group II with furosemide (10 mg/kg, p.o), groups III-V with HIEE, and groups VI-VIII with DHEE, respectively, at 200, 400, and 800 mg/kg doses. After the treatment, animals were individually shifted to metabolic cages for urine collection at 5 and 24 h intervals and studied the urinary electrolytes. Saluretic and natriuretic effects and the index of HIEE and DHEE were calculated.

Results: The results revealed that both extracts considerably (P < 0.05) increased the urine volume and electrolytes (Na+ , K+ , Cl ) compared to the normal control except low dose treatment. DHEE extract at 800 mg/kg dose showed higher diuretic potential than HIEE in the total volume of urine and urinary electrolytes (P < 0.05).

Conclusion: HIEE and DHEE possess diuretic potential, which should be confirmed in human studies.


Implication for health policy/practice/research/medical education:

Hemidesmus indicus and Decalepis hamiltonii ethanolic extracts at various doses showed significant diuretic activity. The diuretic potential of D. hamiltonii at a high dose (800 mg/kg) was higher than H. indicus and hence, D. hamiltonii may be considered as potential diuretic drug.

Please cite this paper as: Thatipelli S, Rethinam G, Reddy GD, Ramachandran S, Pushparathinam G. Diuretic activity and urinary electrolyte effects of Hemidesmus indicus (L.) R.Br. & Decalepis hamiltonii Wight & Arn. in experimental rats. J Herbmed Pharmacol. 2024;13(3):420-426. doi: 10.34172/jhp.2024.48156.

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Submitted: 21 Jul 2023
Accepted: 01 Nov 2023
ePublished: 27 Jun 2024
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