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J Herbmed Pharmacol. 2024;13(1): 101-110.
doi: 10.34172/jhp.2024.48140
  Abstract View: 202
  PDF Download: 134

Original Article

Antioxidant, photoprotective, cytotoxic, and antimicrobial activities of Albuca amoena Batt.

Rajaâ Zakhour 1* ORCID logo, Otman El-Guourrami 2 ORCID logo, Kaoutar Bouothmany 3 ORCID logo, Sobha El Ftouh 4 ORCID logo, Fatima Zahra Benkhouili 5 ORCID logo, Hanane Benzeid 2 ORCID logo, Houssain Tligui 4 ORCID logo, Yahia Cherrah 1 ORCID logo, Laila Benbacer 3 ORCID logo, Katim Alaoui 1 ORCID logo

1 Toxicology and Pharmacodynamy of Aromatic and Medicinal Plants Research Team ERTP.PAM, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat BP 6203, Morocco
2 Laboratory of Analytical Chemistry and Bromatology, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat BP 6203, Morocco
3 Biology and Molecular Research Unit, Department of Life Sciences (CNESTEN), Rabat BP 10001, Morocco
4 Research Laboratory of Ibn Sina Hospital, CHU Ibn Sina, hôpital d’enfants Rabat, rue Lamfadel-Cherkaoui, Rabat BP 6527, Morocco
5 Laboratory of Medicinal Chemistry, Department of Drug Sciences, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat BP 6203, Morocco
*Corresponding Author: Email: rajaazakhour@gmail.com

Abstract

Introduction: Albuca amoena Batt. is an endemic plant from Morocco used for treating melanoma or leishmaniasis. The aim of this study is to test the antioxidant, photoprotective, cytotoxic, and antimicrobial properties of this plant.

Methods: The extracts of the aerial and bulbous parts were obtained by hydroalcoholic maceration of the plant. Their antioxidant potentials were evaluated in vitro using four methods of 2,2-diphenyl-1picrylhydrazil (DPPH), 2,2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP) assay, and total antioxidant capacity assay (TAC). The photoprotective properties were evaluated through the study of UVA and UVB absorbance and antityrosinase activity. The cytotoxic activity was determined against two breast cancer cell lines (MCF-7 and MDA-MB-231) and one human colorectal cancer cell line (HT-29) using the 3-[4,5-Dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method. In addition, the antimicrobial activity was tested on six pathogens: Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus, and Candida albicans by using the disc diffusion method.

Results: The results showed that the UVA and UVB absorptive proprieties of the extracts were similar to those used as positive controls: Methyl salicylate and zinc oxide. Moreover, the antioxidant and antityrosinase properties of the studied extracts were found to be weakly active. The extracts had strong cytotoxicity activities, especially against HT-29 cell line. However, the extracts did not show any antibacterial activity.

Conclusion: According to the results of this study, the extracts can be used as a sunscreen to avoid dermal anomalies and as a new source of cytotoxic bioactive compound.


Implication for health policy/practice/research/medical education:

Our findings reveal that Albuca amoena extracts have a remarkable cytotoxic activity and a beneficial effect on the skin. By carrying out other phytochemical tests, this plant might be used as a source of molecules for drug development.

Please cite this paper as: Zakhour R, El-Guourrami O, Bouothmany K, El Ftouh S, Benkhouili FZ, Benzeid H, et al. Antioxidant, photoprotective, cytotoxic, and antimicrobial activities of Albuca amoena Batt. J Herbmed Pharmacol. 2024;13(1):101-110. doi: 10.34172/jhp.2024.48140.

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Submitted: 14 Jul 2023
Revision: 23 Sep 2023
Accepted: 25 Sep 2023
ePublished: 01 Jan 2024
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