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J Herbmed Pharmacol. 2024;13(1): 10-18.
doi: 10.34172/jhp.2024.48078
  Abstract View: 212
  PDF Download: 170

Review

The survey of antitumor effects of bromelain on neoplastic breast cells: A systematic review

Mohammad Reza Khosravi 1 ORCID logo, Elham Raeisi 2* ORCID logo, Saeid Heidari-Soureshjani 3 ORCID logo, Catherine MT Sherwin 4 ORCID logo

1 Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Pediatric Clinical Pharmacology and Toxicology, Department of Pediatrics, Wright State University Boonshoft School of Medicine, Dayton Children’s Hospital, One Children’s Plaza, Dayton, Ohio, USA
*Corresponding Author: *Corresponding author: Elham Raeisi, Email: , Email: elhamraeisi@gmail.com

Abstract

Background: Breast cancer is one of the most prevalent cancers in women worldwide. Considering the side effects of chemotherapy treatments, we investigated the anticancer effects and mechanisms of bromelain (Br) on breast cancer cells in this systematic review.

Methods: The PRISMA recommendations were followed to design this systematic review. Web of Science, PubMed, Cochrane Library, and Scopus were high-coverage databases used for searching. After considering the inclusion and exclusion criteria for the study, 18 articles were included. The desired information was gathered, entered into an Excel file, and the study outcomes were surveyed.

Results: Br revealed its anticancer effects by preventing the proliferation of cancer cells, inducing cytotoxicity, apoptosis, autophagy, and cellular oxidation in breast cancer cells. Moreover, its anti-inflammatory activity and immunomodulatory effects in the tumor environment can increase treatment outcomes. No significant side effects of this proteolytic substance have been reported, and it is a safe herbal constitution. Its combination with anticancer drugs such as cisplatin has revealed synergic effects. Besides reducing the toxicity of chemotherapy drugs, Br improves treatment outcomes.

Conclusion: Br has shown promising anticancer effects against breast cancer in in vivo and in vitro studies. However, more clinical trial studies are needed to achieve more reliable results.


Implication for health policy/practice/research/medical education:

This study demonstrated the cytotoxic effects of bromelain against breast neoplastic cells and its synergic effects with other chemotherapy drugs. Bromelain indicated anticancer properties by preventing the proliferation of cancer cells, inducing cytotoxicity, apoptosis, autophagy, and cellular oxidation in breast cancer cells. To lessen the side effects of chemotherapy, this herbal remedy may be used in cancer treatment facilities under the guidance of medical professionals.

Please cite this paper as: Khosravi MR, Raeisi E, Heidari-Soureshjani S, Sherwin CM. The survey of antitumor effects of bromelain on neoplastic breast cells: A systematic review. J Herbmed Pharmacol. 2024;13(1):10-18. doi: 10.34172/jhp.2024.48078.

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Submitted: 31 Mar 2023
Revision: 13 Jun 2023
Accepted: 14 Jun 2023
ePublished: 01 Jan 2024
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