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J Herbmed Pharmacol. 2023;12(3): 432-441.
doi: 10.34172/jhp.2023.48

Scopus ID: 85164952488
  Abstract View: 1122
  PDF Download: 649

Original Article

Dual antineoplastic and photodynamic effects of methanolic extract of Tecoma stans yellow flowers for cancer treatment

Asmaa Y Khattab 1 ORCID logo, Nagwa E Awad 2 ORCID logo, Doaa Abdel Fadeel 1* ORCID logo, Maha Fadel 1 ORCID logo

1 Pharmaceutical Nano-Technology Unit, Department of Medical Applications of Laser, National Institute of Laser Enhanced Sciences (NILES), Cairo University, P.O. 12613, Giza, Egypt
2 Pharmacognosy Dept., National Research Centre, Dokki, Giza, Egypt
*Corresponding Author: Doaa Abdel Fadeel, Email: d_fadeel@cu.edu.eg, , Email: doaa.fadeel@niles.edu.eg

Abstract

Introduction: Tecoma stans is a fast-growing plant from the family Bignoniaceae. Various parts of T. stans have been used in different biological applications, especially in cancer treatment. Photodynamic therapy (PDT) is a promising modality for cancer treatment that depends on the interaction between a photosensitizer, light, and oxygen. Searching for photosensitizers from plant origin is crucial to provide nontoxic photosensitizers with high economic value. This study aims to evaluate the anticancer and photodynamic activities of T. stans methanolic flower extract (TSFE).

Methods: The phytoconstituents of TSFE were analyzed by the UPLC/MS/MS technique. The cytotoxicity of TSFE was examined on the breast carcinoma (MCF-7) and lung carcinoma (A549) cell lines, in dark and after irradiation by blue light (400-450 nm).

Results: TSFE contained various phytochemical components with antineoplastic activity. Moreover, TSFE contained coumarins and anthocyanins that may act as photosensitizers. TSFE showed negligible cytotoxicity against MCF-7 cell lines at all tested concentrations in dark. A non-significant cell viability change was observed upon radiation (P>0.05). TSFE showed significant dark cytotoxicity on A549 cells, which improved significantly after light radiation (P<0.05).

Conclusion: TSFE is a promising anticancer and natural photosensitizer for PDT and this study may inspire further ethnobotanical investigations into promising new natural anti-cancers and photosensitizers.


Implication for health policy/practice/research/medical education:

Tecoma stans methanolic flower extract (TSFE) contained coumarins and anthocyanins that may act as photosensitizers. The TSFE showed cytotoxicity against lung cancer and breast cancer cell lines after being irradiated. Therefore, TSFE may be a promising natural photosensitizer to be used in photodynamic therapy of different cancers.

Please cite this paper as: Khattab AY, Awad NE, Fadeel DA, Fadel M. Dual antineoplastic and photodynamic effects of methanolic extract of Tecoma stans yellow flowers for cancer treatment. J Herbmed Pharmacol. 2023;12(3):432-441. doi: 10.34172/ jhp.2023.48.

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Submitted: 01 Mar 2023
Revision: 29 Apr 2023
Accepted: 30 Apr 2023
ePublished: 01 Jun 2023
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