Logo-jhp
J Herbmed Pharmacol. 2023;12(3): 367-379.
doi: 10.34172/jhp.2023.40

Scopus ID: 85165170690
  Abstract View: 1041
  PDF Download: 699

Original Article

Ameliorative effects of phlorotannin-rich fraction of Sargassum tenerrimum in high-fat diet and low dose streptozotocin-induced metabolic changes and oxidative stress in diabetic rats

Narasimha Kumar Godlaveti Vijay ORCID logo, Chitra Vellapandian* ORCID logo

1 Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Chennai, India
*Corresponding Author: Chitra Vellapandian, Email: chitrav@srmist.edu.in

Abstract

Introduction: Type 2 diabetes mellitus (T2D) is a progressing polygenic disease demanding a multitargeted treatment strategy. Sargassum tenerrimum (ST) is a marine brown alga with potentially bioactive chemicals that could be used as innovative biotherapeutics for diabetes treatment. The current research examined the potential of the phlorotannin-rich fraction from S. tenerrimum (PST) to mitigate diabetes in Wistar albino rats induced with high-fat diet (HFD) and streptozotocin (STZ) administration.

Methods: Diabetic rats were given PST (200 and 400 mg/kg) or metformin (250 mg/kg) orally three weeks, and followed by the measurements of insulin, glycemic factors, biological markers of oxidative stress, tumor necrosis factor-alpha (TNF-α), as well as hepatic and pancreatic histopathological changes.

Results: PST treatment significantly decreased fasting blood glucose, insulin resistance, lipid profile, hepatic profile, and TNF- α levels and improved serum insulin and glucose tolerance in diabetic rats. In the skeletal muscles of diabetic rats, PST led to a significant rise in antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) reductase, and a decrease in lipid peroxidation. Furthermore, PST treatment significantly reduced pancreatic-cell damage and hepatic fatty accumulation. PST was more efficacious at 400 mg/kg exhibiting a dose-dependent effect.

Conclusion: PST improves glucolipid metabolism in HFD and STZ-induced diabetic rats, probably by reducing hyperglycemia, insulin resistance, dyslipidemia, oxidative stress, inflammation, and damage to pancreatic and hepatic architectures. The findings suggest that PST has a curative impact on diabetes mellitus type 2 and represents a new subject of study for the treatment of diabetes naturally.


Implication for health policy/practice/research/medical education:

Phlorotannin-rich fraction of Sargassum tenerrimum, a brown marine alga, attenuates hyperglycaemia, insulin resistance, dyslipidemia, and oxidative stress in high-fat diet and streptozotocin-induced diabetic rats. Phlorotannin extracts of S. tenerrimum have the potential to be viable marine drug candidates in the development of anti-diabetic therapeutics.

Please cite this paper as: Godlaveti Vijay NK, Vellapandian C. Ameliorative effects of phlorotannin-rich fraction of Sargassum tenerrimum in high-fat diet and low dose streptozotocin-induced metabolic changes and oxidative stress in diabetic rats. J Herbmed Pharmacol. 2023;12(3):367-379. doi: 10.34172/jhp.2023.40.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1042

Your browser does not support the canvas element.


PDF Download: 699

Your browser does not support the canvas element.

Submitted: 11 Jan 2023
Revision: 28 Apr 2023
Accepted: 01 May 2023
ePublished: 01 Jun 2023
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)