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J Herbmed Pharmacol. 2024;13(2): 208-215.
doi: 10.34172/jhp.2024.44451

Scopus ID: 85192269385
  Abstract View: 192
  PDF Download: 143

Original Article

Combretum aculeatum Vent (Combretaceae) hydroethanolic root bark extract attenuates D-galactoseinduced cognitive impairment, oxidative, and hippocampi dysfunction in mice

Galba Jean Beppe 1 ORCID logo, Bertrand Mpoo Barga 1 ORCID logo, Hervé Hervé Abaissou Ngatanko 1 ORCID logo, Alice Irène Folefack 1 ORCID logo, Nanou Gaël Allah-doum 1 ORCID logo, Merline Nguedia 1 ORCID logo, Alain Bertrand Dongmo 2 ORCID logo, Théophile Dimo 3* ORCID logo

1 Department of Biological Sciences, Faculty of Science, University of Maroua, P.O. Box 814 Maroua, Cameroon
2 Department of Animal Biology, Faculty of Science, University of Douala, P.O. Box 24157 Douala, Cameroon
3 Department of Animal Biology and Physiology, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon
*Corresponding Author: Email: dimo59@yahoo.fr

Abstract

Introduction: Combretum aculeatum is a plant of Combretaceae family. In traditional medicine, it is used to treat schizophrenia. The aim of this study was to assess the possible impacts of hydroethanolic extract of C. aculeatum root bark on D-galactose (D-Gal)-induced amnesia in mice.

Methods: Memory was tested using Y-maze test, radial arms maze (RAM), and new item appreciation. Mice brains were collected for histological and biochemical testing.

Results: Combretum aculeatum substantially (P < 0.001) improved the ratio of spontaneous alternation versus negative control. In addition, discrimination index, and the time required to appreciate the new item were reversed considerably (P < 0.001) in mice receiving the extract opposed to the negative control fraction in the novel object appreciation test. The frequency of working memory mistakes was reversed in receiving extract categories versus negative control animals in RAM essay. Various doses of the extract substantially (P < 0.001) diminished the level of malondialdehyde (MDA), and crucially enlarged superoxide dismutase (SOD) and catalase activity as opposed to the negative control. Furthermore, all doses of the extract had a restructuring effect on the organization of hippocampal cells.

Conclusion: Combretum aculeatum improved cognitive impairment possibly thought its antioxidant activity.


Implication for health policy/practice/research/medical education:

The hydroethanolic extract of Combretum aculeatum reversed cognitive impairment by protecting the central nervous system against free radical damage. Therefore, C. aculeatum might be considered a potential therapeutic agent for neuropathologic diseases.

Please cite this paper as: Beppe GJ, Barga BM, Ngatanko HHA, Folefack AI, Allah-Doum NG, Nguedia M, et al. Combretum aculeatum Vent (Combretaceae) hydroethanolic root bark extract attenuates D-galactose-induced cognitive impairment, oxidative, and hippocampi dysfunction in mice. J Herbmed Pharmacol. 2024;13(2):208-215. doi: 10.34172/jhp.2024.44451.

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Submitted: 16 May 2022
Accepted: 06 Oct 2023
ePublished: 01 Apr 2024
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