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J Herbmed Pharmacol. 2024;13(2): 199-207.
doi: 10.34172/jhp.2024.42388

Scopus ID: 85192272385
  Abstract View: 265
  PDF Download: 172

Original Article

Therapeutic effect of aqueous extract from Ampelocissus africana (Lour) Merr rhizomes on testosterone-induced benign prostatic hyperplasia in Wistar rats

Wendkouni Leila Marie Esther Belem-Kabré 1* ORCID logo, Ollo Da 2 ORCID logo, Ernest Nogma Sombié 1 ORCID logo, Raïnatou Boly 1 ORCID logo, Geoffroy Gueswindé Ouédraogo 1 ORCID logo, Windingoudi Rimwagna Christian Ouédraogo 1,3 ORCID logo, Zakaline Yabré 1,3 ORCID logo, Jean Noel Dado Koussé 1,3 ORCID logo, Lazare Belemnaba 1 ORCID logo, Assita Lamien-Sanou 4 ORCID logo, Noufou Ouédraogo 1,3 ORCID logo

1 Laboratoire de Recherche-Développement de Phytomédicaments et Médicaments (LR-D/PM), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7047 Ouagadougou 03, Burkina Faso
2 Institut Supérieur des Sciences de la Santé (IN.S.SA), Université Nazi Boni, 01 BP 1091 Bobo-Dioulasso 01, Burkina Faso
3 Laboratoire du Développement du Médicament (LADME)/Centre de Formation, de Recherche et d’Expertises en Sciences du Médicament (CEA-CFOREM), Université Joseph KI-ZERBO, Ouagadougou 03 BP 7021, Burkina Faso
4 Département d’Anatomie Pathologique, Centre Hospitalier Universitaire Yalgado Ouedraogo (CHU-YO), 03 BP 7022, Ouagadougou, Burkina Faso
*Corresponding Author: Wendkouni Leila Marie Esther Belem-Kabre,, Email: leilakabre@gmail.com

Abstract

Introduction: Ampelocissus africana is a medicinal plant used to treat several diseases, including those affecting the prostate. This study investigated the effects of the aqueous extract of rhizomes from Ampelocissus africana (AAA) on a testosterone propionate (TP)-induced benign prostatic hyperplasia (BPH) model.

Methods: The effect of the extract at 50, 150, and 300 mg/kg on BPH in male rats was assessed using daily subcutaneous injections of 3 mg/kg TP for four consecutive weeks. After the induction schedule, physical parameters, prostate index (PI), serum biochemical parameters, homogenate antioxidant, enzyme parameters, and prostates histopathological studies were carried out. Triterpenes and sterols were also assessed.

Results: Treatment with AAA reduced the PI level in a dose-dependent manner (up to 75.91% at the dose of 300 mg/kg). The inflammatory marker measured in the present study, namely C-reactive protein, increased significantly in the BPH group and improved with the treatments. In addition, AAA reduced oxidative stress by decreasing the malondialdehyde (MDA) level and increasing the catalase (CAT) and superoxide dismutase (SOD) levels in comparison to the positive control group. A histopathological examination corroborated the result of the analysis of the physical and biochemical parameters. The study also showed interesting levels of triterpenes (119.5 ± 4.5 mg UAE/g) and sterols (104.6 ± 3.06 mg CE/g).

Conclusion: These results suggest that the aqueous extract of Ampelocissus africana could be used as a natural herbal therapy to treat BPH.


Implication for health policy/practice/research/medical education:

This article provides scientific evidence of the protective effect of the aqueous extract from Ampelocissus africana rhizomes to treat benign prostatic hyperplasia. Thus, AAA could be an alternative herbal drug.

Please cite this paper as: Belem-Kabré WLME, Da O, Sombié EN, Boly R, Ouédraogo GG, Ouédraogo WRC, et al. Therapeutic effect of aqueous extract from Ampelocissus africana (Lour) Merr rhizomes on testosterone-induced benign prostatic hyperplasia in Wistar rats. J Herbmed Pharmacol. 2024;13(2):199-207. doi: 10.34172/jhp.2024.42388.

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Submitted: 04 Aug 2023
Accepted: 23 Oct 2023
ePublished: 01 Apr 2024
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