Logo-jhp
J Herbmed Pharmacol. 2022;11(2): 143-153.
doi: 10.34172/jhp.2022.19

Scopus ID: 85129557706
  Abstract View: 2066
  PDF Download: 1114

Review

Efficacy of Vernonia cinerea (L) Less for smoking cessation: An updated meta-analysis of randomized controlled trials

Wiraphol Phimarn 1* ORCID logo, Rotjanawat Sakhancord 1 ORCID logo, Kritsanee Saramunee 1 ORCID logo, Bunleu Sungthong 2 ORCID logo

1 Social Pharmacy Research Unit, Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham, Thailand, 44150
2 Pharmaceutical Chemistry and Natural Products Research Unit, Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham, Thailand, 44150
*Corresponding Author: *Corresponding author: Wiraphol Phimarn, Email: , Email: wiraphol.p@msu.ac.th

Abstract

Vernonia cinerea (VC) has been used for smoking cessation. A previous meta-analysis (MA) reported the efficacy of VC in smoking cessation. However, there have been updated randomized controlled trials (RCTs) on the efficacy of VC for smoking cessation, and the previous MA lacked pooled adverse events (AEs) related to VC. The objective of this study was to systematically review and perform an updated MA on the efficacy of VC for smoking cessation continuous abstinence rate (CAR), prevalence abstinence (PAR), and AE. The research articles were retrieved via electronic databases including PubMed, Science Direct, Web of Science, Thai-Journal Citation Index Center (TCI), and ThaiLis. Ten RCTs published prior to 2019 were included in this study. The number of participants in the studies ranged from 35 to 172, and the follow-up duration for the primary outcomes was 2-12 weeks. Our updated MA found that VC could significantly improve CAR2 (RR=1.54; 95% CI = 1.06, 2.23), CAR4 (RR=1.65; 95% CI = 1.25, 2.17), CAR 8 (RR=1.85; 95% CI = 1.25, 2.75), CAR12 (RR=2.56; 95% CI = 1.66, 3.95), and CAR16 (RR=2.21; 95% CI = 1.03, 4.73). Moreover, VC improved PAR2 (RR=1.47; 95% CI = 1.06, 2.04), PAR4 (RR=1.35; 95% CI = 1.02, 1.79), PAR8 (RR=1.60; 95% CI = 1.11, 2.31), and PAR12 (RR=1.70; 95% CI = 1.25, 2.30). There was no significant difference in the AE between the two groups. The study substantiates claims that VC products are effective in assisting with smoking cessation.

Implication for health policy/practice/research/medical education:

This meta-analysis demonstrated that Vernonia cinerea product is an alternative treatment for smoking cessation.

Please cite this paper as: Phimarn W, Sakhancord R, Saramunee K, Sungthong B. Efficacy of Vernonia cinerea (L) Less for smoking cessation: An updated meta-analysis of randomized controlled trials. J Herbmed Pharmacol. 2022;11(2):143-153. doi: 10.34172/jhp.2022.19.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 2067

Your browser does not support the canvas element.


PDF Download: 1114

Your browser does not support the canvas element.

Submitted: 11 Oct 2021
Revision: 21 Dec 2021
Accepted: 22 Dec 2021
ePublished: 12 Mar 2022
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)