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J Herbmed Pharmacol. 2022;11(2): 238-244.
doi: 10.34172/jhp.2022.28

Scopus ID: 85129476763
  Abstract View: 2358
  PDF Download: 875

Original Article

Assessment of membrane stability, central nervous system depressant, and gut motility effects of Lablab purpureus seeds

Joysree Roy 1 ORCID logo, Sutapa Bhowmik 2 ORCID logo, Md. Giash Uddin 3* ORCID logo, Md. Nazmul Hasan 3 ORCID logo, Abdullah Al Maswood 1 ORCID logo, Sumyya Zahan 3 ORCID logo, Md. Abdul Aziz 1 ORCID logo, Md. Farhad Hossain 4 ORCID logo, Md. Kamrul Hossain 3 ORCID logo, Mohammad Safiqul Islam 1 ORCID logo

1 Department of Pharmacy, Faculty of Science, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
2 Department of Microbiology, Faculty of Science, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
3 Department of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh
4 Department of Physical Therapy, Graduate School of Inje University, Gimhae, Korea
*Corresponding Author: Email: giash.uddin@cu.ac.bd

Abstract

Introduction: Lablab purpureus, under the family of Fabaceae, is a plant with various pharmacological activities. The present study was aimed to investigate the phytoconstituents, membrane stabilizing activity, central nervous system (CNS) depressant potential, and gastrointestinal (GI) motility of the methanol extract of L. purpureus seeds (MELPS).Methods: The methanol plant extract was screened for different phytochemical groups. Mice were classified into four groups for in vivo activities. Group-I was designated as negative control and received distilled water (10 mL/kg body weight); group-II served as positive control and received diazepam (1 mg/kg body weight). Group-III and group-IV both were experimental groups and received plant extract at 200 and 400 mg/kg body weight, respectively.Results: Alkaloids, carbohydrates, saponins, glycosides, tannins, phenols, flavonoids, and proteins were found after phytochemical analysis. On hypotonic solution-induced hemolysis of erythrocyte membrane, MELPS9 (9 mg/mL) resulted in the highest percentage of inhibition (60.51 ± 0.889), and on heat-induced hemolysis, MELPS9 (9 mg/mL) resulted in the highest percentage of inhibition (33.97 ± 0.21). In the case of the CNS depressant potential experiment, mice that received a sample at a dose of 400 mg/kg body weight showed the highest result (54.40 ± 4.51) compared with the positive control (14.2 ± 3.70) (P < 0.001). Similarly, 400 mg/kg dose sample exhibited the highest percentage of inhibition (60.51 ± 0.889) of hemolysis and GI motility (22.26%).Conclusion: It can be concluded that the MELPS has potential membrane stability, CNS depressant, and antimotility effects.

Lablab purpureus methanol seeds extract showed significant membrane stability, CNS depressant, and antimotility effects. The isolation of compounds of this plant might help in drug development programs against inflammation, depression, and diarrhea.
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Submitted: 16 Jun 2021
Revision: 09 Jul 2021
Accepted: 15 Jul 2021
ePublished: 01 Apr 2022
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