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J Herbmed Pharmacol. 2021;10(2): 262-268.
doi: 10.34172/jhp.2021.30

Scopus ID: 85103641500
  Abstract View: 2506
  PDF Download: 1049

Original Article

Sulfoquinovosyl oleoyl palmitoyl glycerol (SQDG) and hexane extract of Sargassum plagyophylum prevent depression induced by dexamethasone or stress in mice

Afsaneh Yegdaneh 1 ORCID logo, Azadeh Mesripour 2* ORCID logo, Marjan Keyvani 2 ORCID logo

1 Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Email: a_mesripour@yahoo.com

Abstract

Introduction: M Glucocorticoids and stress are a leading cause of depression by dysregulation of hypothalamic hypophyseal adrenal axis. Sargassum plagyophylum hexane extract (HxE) has proven antidepressant-like effects in mice. We aimed at evaluating HxE and sulfoquinovosyl oleoyl palmitoyl glycerol (SQDG) isolated compound antidepressant effects following dexamethasone (Dex) or water avoidance stress (WAS) induced depression in mice.

Methods: The HxE was prepared and fractionated by different chromatography methods to isolate active compounds. Depression was induced in male mice by Dex single dose or by four days of WAS. After the locomotor test, depression was assessed by measuring the immobility time during the forced swimming test (FST) and sucrose preference test.

Results: 6-Deoxy-6-sulpho-α-D-glucopyranosyl-1,2-O-diacyl-glycerol was isolated and elucidated from the seaweed. The manipulations did not cause important changes in animals’ locomotor activity. During FST, immobility time increased dramatically by Dex (193 ± 13 s vs control 109 ± 7 s) or WAS (189 ± 13 s vs sham 86 ± 14 s), that indicated depression. HxE 40 mg/kg reduced the immobility time when it was administered with Dex (110 ± 28 s, P < 0.01 vs Dex alone) or together with WAS (86 ± 11 s, P < 0.001 vs WAS). SQDG 40 mg/kg reduced the immobility time when co-administered with Dex (22 ± 9 s, P < 0.001 vs Dex alone) and when it was administered along with WAS (68 ± 16 s, P < 0.001 vs WAS). The results of the sucrose preference test were in line with FST results as sucrose preference below 65% was considered for anhedonia.

Conclusion: SQDG and probably the steroid content in S. plagyophylum HxE prevented depression in mice; thus, they should be considered for further clinical evaluations.


Sargassum plagyophylum hexane extract (HxE) and sulfoquinovosyl oleoyl palmitoyl glycerol (SQDG) isolated compound showed antidepressant effects following dexamethasone or water stress induced depression in mice. Therefore they could be promising alternative medicine for preventing depression in high risk individuals, namely patients under glucocorticoid therapy or under stressful conditions.
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Abstract View: 2507

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Submitted: 10 Aug 2020
Revision: 05 Dec 2020
Accepted: 07 Dec 2020
ePublished: 07 Jan 2021
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