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J Herbmed Pharmacol. 2021;10(2): 166-178.
doi: 10.34172/jhp.2021.18

Scopus ID: 85103633859
  Abstract View: 3089
  PDF Download: 1273

Review

The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agent: proposed mechanisms based on a systematic review

David Andi Wijaya 1 ORCID logo, Melva Louisa 2 ORCID logo, Heri Wibowo 3 ORCID logo, Aslim Taslim 1 ORCID logo, Tiara Bunga Mayang Permata 1 ORCID logo, Handoko Handoko 1 ORCID logo, Endang Nuryadi 1 ORCID logo, Henry Kodrat 1 ORCID logo, Soehartati Argadikoesoema Gondhowiardjo 1* ORCID logo

1 Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital - Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia
2 Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia
3 Laboratorium Terpadu, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia
*Corresponding Author: Email: gondhow@gmail.com

Abstract

Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent.

This systematic review gathers evidence about the anticancer mechanism of Annona muricata while highlights related potential mechanisms of A. muricata as a radio-sensitizer, which can help to enlighten the new radio-sensitizer drug discovery.
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Submitted: 11 Jul 2020
Revision: 14 Sep 2020
Accepted: 29 Sep 2020
ePublished: 05 Jan 2021
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