J Herbmed Pharmacol. 2020;9(1): 68-74.
doi: 10.15171/jhp.2020.10

Scopus ID: 85084237668
  Abstract View: 3574
  PDF Download: 1609

Original Article

Rice bran as source of nutraceuticals for management of cardiovascular diseases, cardio-renal syndrome and hepatic cancer

Sahar Y. Al-Okbi 1* ORCID logo, Doha A. Mohamed 1 ORCID logo, Thanaa E. Hamed 1 ORCID logo, Enas S.K. Al-Siedy 1 ORCID logo

1 Nutrition and Food Sciences Department, National Research Centre, Cairo, Egypt
*Corresponding Author: *Corresponding author: Sahar Y. Al-Okbi, Tel: 00201003785152; Email:, Email: S_Y_alokbi@hotmail.com


Introduction: The interrelation between cardiovascular diseases (CVDs) and renal dysfunction and the beneficial role of nutraceuticals are worthy to be studied. Nutraceuticals with anticancer effects are gaining great importance. The aim of this research was studying the anti-cancer, CVDs prevention and renal dysfunction properties of γ-oryzanol (γ-O) and rice bran oil/γ-O mixture (RBO/γ-O) as nutraceuticals.

Methods: Rats were divided into 7 groups. Group 1 was fed on balanced diet and served as normal control (NC). Group 2 consumed high-fat-sucrose diet (HFSD) as CVD control. Groups 3 and 4 were fed on HFSD and treated by γ-O and RBO/γ-O, respectively. Group 5 was maintained on HFSD with cisplatin injection (cardiorenal syndrome control) (CRSC). Groups 6 and 7 were treated like group 5 and given either γ-O or RBO/γ-O. Plasma lipid profile, malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), catalase activity, creatinine and urea were determined besides urinary creatinine clearance. Nutraceuticals’ anticancer effect was assessed in hepatocellular carcinoma cell (HepG2) line.

Results: Significant increases (P < 0.05) in lipid parameters with reduction of high-density lipoprotein cholesterol (HDL-C) were noticed in CVD control compared to NC group; the same changes were demonstrated in CRSC with lesser extent. In CVD control and CRSC groups; a significant increase (P < 0.05) in MDA and TNF-α with a reduction in catalase were noticed. Kidney dysfunction was demonstrated in the CRSC group. Administration of both RBO/γ-O and γ-O produced variable improvements in all parameters in both models and had anticancer effects.

Conclusion: RBO/ γ-O and γ-O had protective effects on CVDs and cardiorenal syndrome as well as anti-hepatocellular carcinoma activities with superiority of RBO/γ-O.

Implication for health policy/practice/research/medical education:

This study revealed that both γ-oryzanol and γ-oryzanol/rice bran oil mixture could afford protection from CVDs and cardio-renal syndrome and suppression of hepatic carcinoma with superiority to γ-oryzanol/rice bran oil mixture. Therefore, consumption of γ-oryzanol/rice bran oil might be beneficial as preventive remedy for these diseases.

Please cite this paper as: Al-Okbi SY, Mohamed DA, Hamed TE, Al-Siedy ESK. Rice bran as source of nutraceuticals for management of cardiovascular diseases, cardio-renal syndrome and hepatic cancer. J Herbmed Pharmacol. 2020;9(1):68-74. doi: 10.15171/jhp.2020.10.

First Name
Last Name
Email Address
Security code

Abstract View: 3575

Your browser does not support the canvas element.

PDF Download: 1609

Your browser does not support the canvas element.

Submitted: 15 Aug 2019
Accepted: 04 Nov 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)