Ghazal Imani
1 
, Alireza khalilian
2, Dara Dastan
3, Behzad Imani
4 , Maryam Mehrpooya
5* 1 School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Gastroenterology and Hepatology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Pharmacognosy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Operating Room, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran
5 Department of Clinical Pharmacy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract
Introduction: Treatment of Helicobacter pylori has various side effects like antibiotic resistance. The purpose of this study was to evaluate the effects of cinnamon extract on complications of treatment and eradication of H. pylori in infected people.Methods: In this randomized clinical trial, a total of 98 eligible healthy and H. pylori-infected patients approved by esophageal endoscopy were selected. The cinnamon group received multi-drug treatment including clarithromycin, amoxicillin and pantoprazole as well as a cinnamon extract capsule. The control group received multi-drug treatment and a 40 mg starch capsule. In order to analyze the cinnamon extract efficacy, the urea breath test (UBT) was performed 3 months after the start of treatment. Clinical symptoms were evaluated by a questionnaire at the beginning (day of 0), 7 days and 14 days after starting treatment.Results: The clinical symptoms such as nausea, vomiting, diarrhea, constipation, blurred vision, headache, metallic flavor, epigastric pain, burp, and appetite were significantly reduced in cinnamon group (P < 0.05). The odds ratio exhibited a higher eradication rate of H. pylori in cinnamon group (73.47% in cinnamon group compared to 53.06% in the control group) (P = 0.036).Conclusion: Cinnamon as assisted therapy is able to alleviate the disease and reduce the complications of H. pylori treatment.
Implication for health policy/practice/research/medical education:
The use of assisted therapy such as cinnamon increases H. pylori eradication rate and reduces the related side effects. The cinnamon extract might be recommended to physicians as adjunctive therapy for treatment of H. pylori infection.
Please cite this paper as: Imani G, Khalilian A, Dastan D, Imani B, Mehrpooya M. Effects of cinnamon extract on complications of treatment and eradication of Helicobacter pylori in infected people. J Herbmed Pharmacol. 2020;9(1):55-60. doi: 10.15171/ jhp.2020.08.