Effect of Chaerophyllum macropodum extracts on Trichomonas vaginalis in vitro

Maryam Jabari; Gholamreza Asghari; Mostafa Ghanadian; Azizullah Jafari; Hosseiail Yousefi; Rasool Jafari; Seyedeh Marayam Sharafi; Hossein Yousofi Darani

J Herbmed Pharmacol. 2015;4(2): 61-64.

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Original Article

Effect of Chaerophyllum macropodum extracts on Trichomonas vaginalis in vitro

Maryam Jabari ¹, Gholamreza Asghari ¹, Mostafa Ghanadian ¹, Azizullah Jafari ¹, Hosseiail Yousefi ², Rasool Jafari ², Seyedeh Marayam Sharafi ³, Hossein Yousofi Darani ²^*

¹ Department of Phamacagnozi, Isfahan University of Medical Sciences, Isfahan, Iran
² Department of Parasitology, Isfahan University of Medical Sciences, Isfahan, Iran
³ Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

*Corresponding Author: *Corresponding author: Prof. Hossein Yousofi Darani, Department of Parasitology, Isfahan University of Medical Sciences, Isfahan, Iran. , Email: Yousofidarani@gmail.com

Abstract

Introduction: Trichomonas vaginalis (T. vaginalis) is a protozoan parasite causing trichomoniasis or trichomonal vaginitis. The infection is considered as non-viral sexually transmitted disease (STD). Metronidazole and Tinidazole are now the drugs of choice for the treatment of this infection. However, resistant to these drugs has also been reported. So it is necessary to search for effective alternative drugs with fewer side effects. Chaerophyllum macropodum (C. macropodum) plant have been used against some parasites. Therefore, in this study the effects of different extracts of this plant on T. vaginalis in culture media have been investigated.

Methods: In this experimental study hydro-ethanol extracts of C. macropodum leaves were prepared. Anti-T. vaginalis activities of the extracts were tested in concentrations of 2, 4, 8, 16, 32, 40, 50, 60, 80, 100 and 150 mg/ml following 24, 48 and 72 hours of incubation of cultured media.

Results: All extract concentrations showed some degrees of growth inhibition activity on T. vaginalis. However crude extract was more efficient.

Conclusion: C. macropodum showed an anti-T. vaginalis activity. More investigations are recommended to use this plant as an antiparasitic drug.

Keywords: Trichomonas vaginalis, Chaerophyllum macropodum, Trichomoniasis, Hydro-Alcoholic Extract

Implication for health policy/practice/research/medical education:

The results of this study showed that the different extracts of C. macropodum with different concentrations have anti-trichomonal activity, and might be used in human.

Please cite this paper as: Jabari M, Asghari G, Ghanadian M, Jafari A, Yousefi H, Jafari R, et al. Effect of Chaerophyllum macropodum extracts on Trichomonas vaginalis in vitro. J HerbMed Pharmacol 2015; 4(2): 61-64.

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