Hepatoprotective and Hypolipidemic Effects of Carthamus tinctorius oil in Alloxan-induced Type 1 Diabetic Rats

Parivash Rahimi; Sedigheh Asgary; Najmeh Kabiri

J Herbmed Pharmacol. 2014;3(2): 107-111.

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Original Article

Hepatoprotective and Hypolipidemic Effects of Carthamus tinctorius oil in Alloxan-induced Type 1 Diabetic Rats

Parivash Rahimi ¹, Sedigheh Asgary ²^*, Najmeh Kabiri ³

¹ Department of Biology, Faculty of Sciences, Isfahan University, Isfahan, Iran
² Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
³ Shahrekord University of Medical Sciences, Shahrekord, Iran

*Corresponding Author: *Corresponding author: Sedigheh Asgary, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. , Email: sasgary@yahoo.com

Abstract

Introduction: Hepatoprotective and hypolipidemic effects of Carthamus tinctorius Linn.(Safflower) seed oil was investigated in diabetic rats.

Methods: Diabetes was induced by administration of 120 mg/kg alloxan monohydrate. The seed oil of safflower at dose of 200 mg/kg was administered as single dose per day to diabetic rats for a period of 28 days. The effect of oil on blood glucose level was measured in the diabetic rats. Serum lipid profile [total cholesterol (TC), triglycerides (TGs), low density (LDL) and high density lipoprotein (HDL) and enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were also determined.

Results: Levels of blood glucose, TC, TGs, LDL, ALT, AST and ALP decreased and HDL increased in alloxan induced diabetic rats after treatment with 200 mg/kg safflower seed oil for 28 days.

Conclusion: The present study demonstrates that seed oil of safflower seems to be useful for the prevention of diabetes complications.

Keywords: Carthamus tinctorius, Safflower oil, Hepatoprotection, Hypolipidemia

Implication for health policy/practice/research/medical education:

The present study demonstrates that safflower seed oil might to be useful for the prevention of diabetes complications including hepatotoxicity and hyperlipidemia.

Please cite this paper as: Rahimi P, Asgary S, Kabiri N. Hepatoprotective and Hypolipidemic Effects of Carthamus tinctorius oil in Alloxan-induced Type 1 Diabetic Rats. J Herbmed Pharmacol. 2014; 3(2): 107-111.

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