J Herbmed Pharmacol. 2016;5(3): 99-102.
  Abstract View: 3441
  PDF Download: 2180

Original Article

Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function

Nilofar Amidi 1, Shirin Moradkhani 2, Mahsa Sedaghat 2, Nejat Khiripour 1, 3, Amir Larki-Harchegani 4, Nahid Zadkhosh 4, Mahmoud Mirhoseini 5, Akram Ranjbar 4*

1 Student Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Pharmacognosy and pharmaceutical biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
5 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding Author: Email: akranjbar2015@gmail.com


Introduction: Cisplatin is one of the most potent chemotherapeutic antitumor drugs. Also, oxidative stress has been established to be involved in cisplatin-induced toxicity. Therefore, the present study was undertaken to examine the antioxidant and anti-inflammation potential of green tea hydroalcoholic extract (GTE) against the liver function of cisplatin in male rats.Methods: Adult male Wistar rats (180–250 g) were divided into 4 groups (n = 5) treated as follows: (1) control group (saline solution, 1 ml kg−1 body weight, i.p.), cisplatin group (7 mg kg−1 body weight, i.p.). Animals of Groups III received only green tea extract (30 mg/kg/day, by gavage). Group IV was given green tea extract+ cisplatin once daily for 24 hours. Liver function was evidenced in the cisplatin group by the increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The mechanism of cisplatin induced liver function was considered as being decreased the total antioxidant power (TAP). Systemic inflammation was assessed by tumor necrosis factor-alpha (TNF-α) levels.Results: A decrease in TAP level in cisplatin group was observed compared with control group. GTE administration decreased TNF-α and increased TAP compared to cisplatin group, but showed no significant differences between groups.Conclusion: The results suggested that green tea could ameliorate cisplatin liver function in rats through reduction of oxidative toxic stress and inflammation.
First Name
Last Name
Email Address
Security code

Abstract View: 3442

Your browser does not support the canvas element.

PDF Download: 2180

Your browser does not support the canvas element.

Revision: 03 Jun 2016
ePublished: 29 Jun 2016
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)