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J Herbmed Pharmacol. 2020;9(1): 28-34. doi: 10.15171/jhp.2020.04

Original Article

Antitumor activity of methoxylated flavonoids separated from Achillea fragrantissima extract in Ehrlich’s ascites carcinoma model in mice

Basma M. Awad 1 ORCID, Mohammad M. Abd-Alhaseeb 2 * ORCID, Eman S. Habib 3, Amany K. Ibrahim 3, Safwat A. Ahmed 3

Cited by CrossRef: 5

1- Rehman N, Salkini M, Alanizi H, Alharbi A, Alqarni M, Abdel-Kader M. Achillea fragrantissima Essential Oil: Composition and Detailed Pharmacodynamics Study of the Bronchodilator Activity. Separations. 2022;9(11):334 [Crossref]
2- Elhady S, Eltamany E, Shaaban A, Bagalagel A, Muhammad Y, El-Sayed N, Ayyad S, Ahmed A, Elgawish M, Ahmed S. Jaceidin Flavonoid Isolated from Chiliadenus montanus Attenuates Tumor Progression in Mice via VEGF Inhibition: In Vivo and In Silico Studies. Plants. 2020;9(8):1031 [Crossref]
3- Eltamany E, Goda M, Nafie M, Abu-Elsaoud A, Hareeri R, Aldurdunji M, Elhady S, Badr J, Eltahawy N. Comparative Assessment of the Antioxidant and Anticancer Activities of Plicosepalus acacia and Plicosepalus curviflorus: Metabolomic Profiling and In Silico Studies. Antioxidants. 2022;11(7):1249 [Crossref]
4- Alkhatib R. Chemical Composition of Essential Oils Total Phenols and Antioxidant Activity of Achillea fragrantissima and A. santolina Grown in Syria. Jordan j pharm sci. 2024;17(3):594 [Crossref]
5- Shehatta N, Okda T, Omran G, Abd-Alhaseeb M. Baicalin; a promising chemopreventive agent, enhances the antitumor effect of 5-FU against breast cancer and inhibits tumor growth and angiogenesis in Ehrlich solid tumor. Biomedicine & Pharmacotherapy. 2022;146:112599 [Crossref]
6- Benali T, Jaouadi I, Ghchime R, El Omari N, Harboul K, Hammani K, Rebezov M, Shariati M, Mubarak M, Simal-Gandara J, Zengin G, Park M, Kim B, Mahmud S, Lee L, Bouyahya A. The Current State of Knowledge in Biological Properties of Cirsimaritin. Antioxidants. 2022;11(9):1842 [Crossref]
7- Break M, Hussein W, Alafnan D, Almutairi H, Katamesh A, Alshammari M. Achillea fragrantissima (Forssk.) Sch. Bip. essential oil inhibits the growth of pancreatic cancer cells via induction of necrosis, sub-G1 arrest, modulation of β-catenin/ERK signalling pathways and p38α MAPK, CDK2, EGFR inhibition. Journal of Ethnopharmacology. 2025;352:120201 [Crossref]

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