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  Abstract View: 84

Original Article

Antidiabetic activity of tannin fraction of Bridelia ferruginea (Benth) leaf extract on fructose-induced diabetic mice

Sabrina Sanvee 1 ORCID logo, Oudjaniyobi Simalou 1* ORCID logo, Gneiny Whad Tchani 1 ORCID logo, Hèzouwè Kagnou 1 ORCID logo, Batomayena Bakoma 2 ORCID logo, Kossi Metowogo 3 ORCID logo, Kokou Agbékonyi Agbodan 4 ORCID logo, Kafui Kpegba 1 ORCID logo

1 Laboratoire de Chimie Organique et des Substances Naturelles, Faculté des Sciences, Université de Lomé, 01 BP 1515 Lomé 01, Lomé, Togo
2 Faculté des sciences de la santé, Université de Lomé, 01 BP 1515 Lomé 01, Lomé, Togo
3 Laboratoire de physiologie/Pharmacologie, Faculté des sciences, Université de Lomé, 01 BP 1515 Lomé 01, Lomé, Togo
4 Laboratoire de Génie des Procédés et Ressources Naturelles, Département de Chimie, Université de Lomé, 01 BP 1515 Lomé 01, Lomé, Togo

Abstract

Introduction: Bridelia ferruginea is a plant known for its antidiabetic properties. However, few studies on leaf extracts have induced anti-hyperglycemic activity on normal mice subjected to carbohydrate overload. The current study was designed to assess the effect of the leaf extracts’ fraction on fructose-induced diabetic mice. Methods: The in vitro ferric-reducing antioxidant power (FRAP) assay were carried out and the condensed tannins quantified. The vanillin-HCl method was used to characterize the condensed tannins. The antidiabetic effect on fructose-induced diabetic mice was evaluated for 28 days using a fructose-enriched fat diet approach. Results: The fraction confirmed the antioxidant activity with a reducing power of 800 μg/mL comparable to ascorbic acid at 200 μg/mL. The condensed tannins were estimated at 79.6 ± 3.4 mg catechin equivalent per gram of sample. Significant decreases in blood sugar levels of 6.25% at the 7th day, 11.04% at the 14th day, 12.61% at the 21th day, and 11.35% at the 28th day were obtained in mice treated with the extract dose of 200 mg/kg of body weight, compared to the positive control group. The decreases of 37.11% of triglycerides and 40.16% of total cholesterol were also obtained. Conclusion: The investigated fraction showed notable antidiabetic activity and might be a good candidate in the treatment of diabetes.
Keywords: Bridelia ferruginea, Tanin-fraction, Antidiabetic, Lard-fructose
The tannin treated fraction of hydro-ethanolic extract of B. ferruginea leaves could be used in the treatment of type 2 diabetes in order to regulate glycaemia and in the decrease of oxidative stress and severe diabetes like hypercholesterolemia.
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Submitted: 09 Jul 2020
Revision: 02 Oct 2020
Accepted: 02 Oct 2020
ePublished: 20 Oct 2020
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