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  Abstract View: 44

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The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agent: proposed mechanisms based on a systematic review

David Andi Wijaya 1 ORCID logo, Melva Louisa 2 ORCID logo, Heri Wibowo 3 ORCID logo, Aslim Taslim 1 ORCID logo, Tiara Bunga Mayang Permata 1 ORCID logo, Handoko Handoko 1 ORCID logo, Endang Nuryadi 1 ORCID logo, Henry Kodrat 1 ORCID logo, Soehartati Argadikoesoema Gondhowiardjo 1* ORCID logo

1 Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital - Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia
2 Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia
3 Laboratorium Terpadu, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia

Abstract

Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent.
Keywords: Annona muricata L., Radiotherapy, Radiosensitivity, Plant extract, Bioactive compounds, mechanism
This systematic review gathers evidence about the anticancer mechanism of Annona muricata while highlights related potential mechanisms of A. muricata as a radio-sensitizer, which can help to enlighten the new radio-sensitizer drug discovery.
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Submitted: 11 Jul 2020
Revision: 14 Sep 2020
Accepted: 29 Sep 2020
ePublished: 05 Jan 2021
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