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J Herbmed Pharmacol. 2021;10(2): 232-240.
doi: 10.34172/jhp.2021.26
  Abstract View: 215
  PDF Download: 34

Original Article

Gastroprotective effect of mucilage fraction from Solenostemma argel via cytoprotection and attenuation of oxidative stress, inflammation and apoptosis

Riham Adel El-Shiekh 1* ORCID logo, Abeer Salama 2 ORCID logo, Asmaa Al-Mokaddem 3 ORCID logo, Essam A. Abdel-Sattar 1 ORCID logo

1 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr el Aini st., Cairo 11562, Egypt
2 Department of Pharmacology, Medical Division, National Research Centre, El-Bouhouth St., Cairo, 12622, Egypt
3 Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza Square, Giza 12211, Egypt

Abstract

Introduction: Polysaccharides have numerous therapeutic values including immunity stimulation, angiotensin converting enzyme inhibition, wound healing, anti-diabetic and cytotoxic activities, in addition to their potent anti-oxidant properties. This work examined the gastroprotective and ulcer healing potential of mucilage fraction isolated from Solenostemma argel (Delile) Hayne (MFA) against ethanol-induced gastric ulcer in rats. Methods: Forty Sprague-Dawley rats were divided into five groups (n=8); normal control (I), ethanol control (II), 20 mg/kg Antodine pretreated rats (III), 100 mg/kg, and 200 mg/kg MFA pretreated rats, respectively (IV & V). All rats in groups II-V received single intragastric dose of ethanol (5 mL/kg) to induce gastric ulcer. Gastric mucosal injuries were assessed by stomach gross examination as well as histopathology, and immunohistochemistry of apoptotic markers. Also, several biochemical parameters including oxidative stress, proinflammatory cytokines, cytoprotective and cell proliferative biomarkers were measured. Results: High-performance liquid chromatography (HPLC) analysis of MFA revealed its composition of glucose, D-fucose and N-acetyl glucosamine as monosaccharaides, in addition to glucuronic and galacturonic acids. The data showed that MFA, 200 mg/kg had potent antioxidant, anti-inflammatory, cytoprotective, cell proliferative, and antiapoptotic activities which were better than Antodine.Conclusion: This study revealed that MFA had significant gastroprotective effects against ethanol-induced gastric injuries and could be a promising adjuvant therapy for ulcer treatment.
Keywords: Gastric ulcer, Mucilage, Cytoprotection, Cell proliferation, Apoptosis, Oxidative stress
Mucilage fraction of Solenostemma argel (Delile) Hayne exhibited potent anti-oxidant, anti-inflammatory, cytoprotective, cell proliferative, and antiapoptotic activities, which may have significant implications for the future development of anti-ulcer drugs derived from Argel.
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Submitted: 08 Jul 2020
Revision: 27 Aug 2020
Accepted: 27 Aug 2020
ePublished: 07 Jan 2021
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