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J Herbmed Pharmacol. 2020;9(2): 153-160.
doi: 10.34172/jhp.2020.20
  Abstract View: 549
  PDF Download: 99

Original Article

The hepatoprotective effect of Cheral as anti-oxidant and anti-inflammation on mice (Mus musculus) with breast cancer

Feri Eko Hermanto 1 ORCID logo, Aris Soewondo 1 ORCID logo, Hideo Tsuboi 2 ORCID logo, Mansur Ibrahim 3 ORCID logo, Muhaimin Rifa'i 1, 4* ORCID logo

1 Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran Malang 65145, East Java, Indonesia
2 Department of Immunology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
3 Pancasakti University, Makasar 90132, South Sulawesi, Indonesia
4 Biosystem Study Center, Brawijaya University, Jl. Veteran Malang 65145, East Java, Indonesia
*Corresponding author: Muhaimin Rifa’i, Email: immunobiology@ub.ac.id

Abstract

Introduction: Recent studies have reported that breast cancer may affect the physiology of other organs, including oxidative stress in the liver. On the other hand, some agents such as white turmeric (Curcuma longa) and Meniran (Phyllanthus niruri) seem to maintain redox stability and immunomodulation. Both of them are combined into Cheral potion. This study was aimed to investigate the Cheral efficacy in modulating oxidative stress based on Nuclear factor erythroid 2-related factor 2 (Nrf2), HEME OXIGenase (HO), and superoxide dismutase (SOD) levels as well as pro-inflammatory cytokines under breast cancer condition in vivo.

Methods: Nrf2, HO, and SOD from hepatocytes, and tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) from splenocytes were measured by flow cytometry after 14 days of Cheral administration.

Results: The results showed that mice model for breast cancer underwent oxidative stress denoted by high levels of HO, and SOD accompanied by increased levels of TNF-α and IFN-γ in the cancer group compared to normal healthy group (P<0.05). In contrast, Cheral treatment was able to modulate redox balance by declining levels of HO, SOD, TNF-α, and IFN-γ, but not Nrf2, compared to cancer group (P<0.05).

Conclusion: The results showed that breast cancer could alter the host’s physiology, including liver oxidative stress. The levels of TNF-α and IFN-γ might contribute to regulation of redox balance in the liver. However, Cheral has potency as an alternative therapeutic agent to reduce oxidative stress in the liver under breast cancer condition.

Keywords: Breast cancer, Cheral, Liver oxidative stress, Proinflammatory cytokines

Implication for health policy/practice/research/medical education:

Cheral showed to be a good therapeutic alternative to prevent oxidative stress and inflammation during breast cancer progression. Hence, it might be beneficial in patients with these conditions, especially the ones with breast cancer.

Please cite this paper as: Hermanto FE, Soewondo A, Tsuboi H, Ibrahim M, Rifa’i M. The hepatoprotective effect of Cheral as anti-oxidant and anti-inflammation on mice (Mus musculus) with breast cancer. J Herbmed Pharmacol. 2020;9(2):153-160. doi: 10.34172/jhp.2020.20.

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Submitted: 23 Oct 2019
Accepted: 31 Dec 2019
ePublished: 14 Feb 2020
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