J Herbmed Pharmacol. 2020;9(1):61-67.
doi: 10.15171/jhp.2020.09
  Abstract View: 30
  PDF Download: 35

Original Article

Effects of gallic acid on rat testopathy following morphine administration: an experimental study

Cyrus Jalili 1 ORCiD, Amir Abdolmaleki 2 ORCiD, Shiva Roshankhah 2 ORCiD, Mohammad Reza Salahshoor 2 * ORCiD

1 Medical Biology Research Center, Department of Anatomical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding author: Mohammad Reza Salahshoor, Email: Email: reza.salahshoor@yahoo.com

Abstract

Introduction: Morphine (MOR) as a psychoactive agent in the opium family causes free radicals accumulation which leads to failure in spermatogenesis. Gallic acid (GA), a polyphenolic acid, is found in various plants with antioxidant, anti-fungal, anti-viral, and anti-allergic activities. The purpose of this study was to evaluate the effects of GA against MOR-induced damage to the reproductive parameter of rats.

Methods: Sixty-four male Wistar rats (8 weeks, 220-250 g) were categorized into 8 groups by random (n=8/each); normal control and MOR control groups; GA groups (5, 10, 20 mg/kg) and MOR + GA groups (5, 10, 20 mg/kg). Treatments were administered intraperitoneally (i.p), daily for 4 weeks. The sperm parameters, spermatogenesis index (SI), total antioxidant capacity, testosterone level, and seminiferous tube diameter (STD) were assessed.

Results: All sperm parameters reduced significantly in the MOR control group than to the normal control group (P < 0.01). All parameters were significantly improved in GA and GA + MOR treatment groups compared to the MOR control group (P < 0.01).

Conclusion: MOR caused a detrimental effect on male reproductive parameters. Also, no significant modifications were observed in all doses of GA treatments in comparison with the normal control group. GA compensates the toxic effect of MOR on reproductive parameters. Hence, GA administration is beneficial in MOR users.

Implication for health policy/practice/research/medical education:

Gallic acid can significantly reduce the morphine related damages in male reproductive parameters through antioxidant properties. Hence, its consumption is recommended in morphine consumers.

Please cite this paper as: Jalili C, Abdolmaleki A, Roshankhah SH, Salahshoor MR. Effects of gallic acid on rat testopathy following morphine administration: an experimental study. J Herbmed Pharmacol. 2020;9(1):61-67. doi: 10.15171/jhp.2020.09.

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Submitted: 01 Jun 2019
Accepted: 03 Sep 2019
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