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J Herbmed Pharmacol. 2020;9(2): 105-111.
doi: 10.34172/jhp.2020.14
  Abstract View: 14

Review

Puerarin as potential treatment in diabetic retinopathy

Mohammad Fathalipour 1 ORCID logo, Amir Mahmoodzadeh 2 ORCID logo, Omid Safa 3 ORCID logo, Hossein Mirkhani 4, 5 * ORCID logo

1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2 Department of Biochemistry, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Clinical Pharmacy, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
4 Department of Pharmacology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5 Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Diabetic retinopathy (DR) is one of the most prevalent microvascular complications of diabetes, and the most leading cause of visual loss around the world. The lack of effective and approved treatment in DR is a major challenge for diabetic patients. Nowadays, natural compounds have got the attention of the researchers for management of DR. Many evidences suggest that puerarin as a natural polyphenol exerts advantageous effects against DR. In the present review, we summarized the protective effects of puerarin against DR, and discussed the underlying mechanisms of these effects. Puerarin attenuates retinal neovascularization and neurodegeneration in diabetes mellitus, and the underlying mechanisms are related to antioxidant, anti-inflammatory, and antiapoptotic properties of the compound. In conclusion, puerarin might be a potential adjuvant agent for the prevention and treatment of DR. However, comprehensive studies are necessary to show its effectiveness and safety, particularly in human.
Keywords: Diabetic retinopathy, Puerarin, Antioxidant, Anti-inflammatory agent, Antiapoptotic agent
Puerarin is one of the most famous isoflavones, which currently is used as an adjuvant agent in the treatment of different pathological conditions. Reviewing available evidences on the pharmacological activities and its underlying mechanisms can be helpful in the future treatment of retinopathy among diabetic patients.
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Submitted: 20 Jul 2019
Revision: 23 Jul 2019
Accepted: 23 Jul 2019
ePublished: 14 Feb 2020
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