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J Herbmed Pharmacol. 2020;9(1): 42-47.
doi: 10.15171/jhp.2020.06
  Abstract View: 319
  PDF Download: 129

Original Article

Feverfew attenuates carbon tetrachloride-induced testicular damage in rats

Mohammad Mazani 1 ORCID logo, Shokofeh Banaei 2, 3 ORCID logo, Lotfollah Rezagholizadeh 1 * ORCID logo

1 Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
2 Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
3 Social Determinants of Health (SDH) Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
*Corresponding author: Lotfollah Rezagholizadeh, Email: reza34055@gmail.com

Abstract

Introduction: Feverfew is an herbal medicine with the traditional usage of treating several disorders. Some investigations have demonstrated that feverfew is an effective remedy for the prophylactic treatment of inflammatory conditions, migraine and menstrual disorders. Therefore, this study was arranged out to evaluate the protective or curative potentials of feverfew methanolic extract (FME) on carbon tetrachloride (CCl4) induced oxidative trauma in testis.

Methods: In this experiment, male Wistar rats were divided into seven groups (n=6). Group I as a normal control received 1 mL/kg distilled water for 14 days orally and on the 14th-day olive oil (1.5 mL/kg, i.p.). Group II received 1 mL/kg distilled water orally for 14 consecutive days. Groups III, IV and V animals were pretreatment groups and treated with three different doses of FME (40, 80, and 120 mg/kg, p.o, respectively) for 14 days. All groups except group one, were also intoxicated with 1.5 ml CCl4 (i.p, in a 1:1 dilution with olive oil) on the 14th day. Groups VI and VII were post-treatment groups and received FME (80 and 120 mg/kg, p.o, respectively) at 2, 6, 24 and 48 h after CCl4 injection.

Results: Injection of CCl4 significantly (P < 0.001) reduced antioxidant enzymes (SOD and GPx) and increased malondialdehyde when compared to the control group. Administration of FME significantly (P < 0.05) improved these alterations near to control rats.

Conclusion: It is suggested that FME has the ability to protect testis against oxidative damage, possibly through antioxidant effects of its bioactive compounds.

Keywords: Feverfew, Carbon tetrachloride, Testicular damage, Antioxidant, Rat

Implication for health policy/practice/research/medical education:

Feverfew has potent antioxidant activities such as free radical scavenging potential. Therefore, alcoholic extract of feverfew may be used as a protective agent on testis tissues in carbon tetrachloride induced oxidative stress.

Please cite this paper as: Mazani M, Banaei S, Rezagholizadeh L. Feverfew attenuates carbon tetrachloride-induced testicular damage in rats. J Herbmed Pharmacol. 2020;9(1):42-47. doi: 10.15171/jhp.2020.06.

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Abstract View: 319

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Submitted: 09 May 2019
Accepted: 24 Aug 2019
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