J Herbmed Pharmacol. 2019;8(4):295-301.
doi: 10.15171/jhp.2019.43
  Abstract View: 41
  PDF Download: 33

Original Article

Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in mice

Basma M. Abdelaziz 1 ORCiD, Maged W Helmy 1, Mohamed A Katary 1, Mohammad M. Abd-Alhaseeb 1 * ORCiD, Asser I. Ghoneim 1

1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt

Abstract

Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder that has no definite cure. Currently, there is great interest in using plant-based medicines to treat AD. In the present study, the neuroprotective effects of Astragalus kahiricus root extract were evaluated in a retrograde amnesia model.Methods: Male albino mice were given four training sessions in the Morris water maze for seven consecutive days. Treated groups were administered A. kahiricus (25 or 50 mg/kg, i.p.) before ethanol (3.5 gm/kg, i.p) injection. All animals were given a test session in the Morris water maze apparatus. Acetylcholinesterase activity and the levels of oxidative stress biomarkers were also measured.Results: Memory impairment was observed, after ethanol administration, as increased escape latency time and path length travelled by the animals. On the other hand, A. kahiricus significantly reduced both escape latency time and path length. In addition, the extract demonstrated an inhibitory effect on acetylcholinesterase activity and total nitrite level. Moreover, A. kahiricus significantly increased the level of reduced glutathione in mice brain.Conclusion: This study demonstrated the potential behavioural and biochemical neuroprotective properties of A. kahiricus root extract, which might further be considered an important candidate for the treatment of AD.
Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder that has no definite cure. Currently, there is great interest in using plant-based medicines to treat AD. In the present study, the neuroprotective effects of Astragalus kahiricus root extract were evaluated in a retrograde amnesia model.Methods: Male albino mice were given four training sessions in the Morris water maze for seven consecutive days. Treated groups were administered A. kahiricus (25 or 50 mg/kg, i.p.) before ethanol (3.5 gm/kg, i.p) injection. All animals were given a test session in the Morris water maze apparatus. Acetylcholinesterase activity and the levels of oxidative stress biomarkers were also measured.Results: Memory impairment was observed, after ethanol administration, as increased escape latency time and path length travelled by the animals. On the other hand, A. kahiricus significantly reduced both escape latency time and path length. In addition, the extract demonstrated an inhibitory effect on acetylcholinesterase activity and total nitrite level. Moreover, A. kahiricus significantly increased the level of reduced glutathione in mice brain.Conclusion: This study demonstrated the potential behavioural and biochemical neuroprotective properties of A. kahiricus root extract, which might further be considered an important candidate for the treatment of AD.
First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 41

Your browser does not support the canvas element.


PDF Downloaded: 33

Your browser does not support the canvas element.

Submitted: 17 Mar 2019
Revised: 01 Jun 2019
Accepted: 08 Jun 2019
First published online: 01 Sep 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)