J Herbmed Pharmacol. 2019;8(1):28-34.
doi: 10.15171/jhp.2019.05
  Abstract View: 194
  PDF Download: 199

Original Article

Protective and anti-inflammatory effects of silymarin on paraquat-induced nephrotoxicity in rats

Ali Sharifi-Rigi 1, Esfandiar Heidarian 2 * ORCiD

1 Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Abstract

Introduction: Paraquat is a quaternary nitrogen herbicide which induces kidney toxicitydue to producing oxidative stress. We have investigated the potential protective effects ofsilymarin on paraquat-induced renal toxicity.Methods: Twenty-four male rats were divided into three groups, group 1, control group;group 2, rats that received paraquat only (25 mg/kg b.w./day, po); animals in group 3, wastreated with paraquat (25 mg/kg b.w./day, po) and silymarin (50 mg/kg b.w./day, po). Then,the serum and tissue parameters of the oxidative stress and renal histopathological changeswere examined.Results: In group 2 which received paraquat only, a remarkable increase (P<0.05) was observedin serum creatinine, urea, malondialdehyde (MDA), protein carbonyl, and tumor necrosisfactor alpha (TNF-α). Also, there was a significant decrease in renal superoxide dismutase,catalase (CAT), ferric reducing ability of plasma (FRAP) and vitamin C in the second group.Oral administration of silymarin significantly decreased serum urea, creatinine, proteincarbonyl, MDA, and TNF-α as well as renal histopathological changes.Conclusion: The present study suggests that silymarin has anti-inflammatory andnephroprotective effects against nephrotoxicity caused by paraquat.
Introduction: Paraquat is a quaternary nitrogen herbicide which induces kidney toxicitydue to producing oxidative stress. We have investigated the potential protective effects ofsilymarin on paraquat-induced renal toxicity.Methods: Twenty-four male rats were divided into three groups, group 1, control group;group 2, rats that received paraquat only (25 mg/kg b.w./day, po); animals in group 3, wastreated with paraquat (25 mg/kg b.w./day, po) and silymarin (50 mg/kg b.w./day, po). Then,the serum and tissue parameters of the oxidative stress and renal histopathological changeswere examined.Results: In group 2 which received paraquat only, a remarkable increase (P<0.05) was observedin serum creatinine, urea, malondialdehyde (MDA), protein carbonyl, and tumor necrosisfactor alpha (TNF-α). Also, there was a significant decrease in renal superoxide dismutase,catalase (CAT), ferric reducing ability of plasma (FRAP) and vitamin C in the second group.Oral administration of silymarin significantly decreased serum urea, creatinine, proteincarbonyl, MDA, and TNF-α as well as renal histopathological changes.Conclusion: The present study suggests that silymarin has anti-inflammatory andnephroprotective effects against nephrotoxicity caused by paraquat.
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Submitted: 19 Apr 2018
Revised: 30 Nov 2018
Accepted: 01 Dec 2018
First published online: 02 Jan 2019
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