eISSN: 2345-5004
Editorial Board
Aims and Scope
Current Issue
All Issues
Search
Sitemap
Contact Us
Rss

Open Access

ICMJE

WAME

Renal Pathology Society

publication ethics

Journal of Herbmed Pharmacology 2017;6(4):178-184. doi:
The Effects of Glycyrrhiza glabra L. extract use with aerobic training on inflammatory factors and cognitive state in elderly with mild cognitive impairment

Original Article

Mohammad-Ali Kohanpour 1, Maghsoud Peeri 2, Mohammad-Ali Azarbayjani 2

1 PhD Candidate, Department of Exercise Physiology, Islamic Azad University, Central Tehran branch, Iran
2 Professor, Department of Exercise Physiology, Islamic Azad University, Central Tehran Branch, Iran


Abstract
Introduction: This study was aimed to investigate the effect of a 12-week aerobic training protocol and treatment with Glycyrrhiza glabra extract on serum interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) levels and cognitive state in the elderly with mild cognitive impairment (MCI).Methods: Forty people who attained scores 21-25 on the Mini–Mental State Examination (MMSE) were selected by purposive and convenience sampling and randomly assigned to four groups of 10 each: training, G. glabra-treated, training+G. glabra-treated, and placebo. All interventions were conducted within 12 weeks. Aerobic training protocol consisted of an 8-minute running at an intensity of 75%-85% maximum heart rate in the first session. One minute was added to the duration of running per two sessions so that after 12 weeks, the duration of running in two last sessions was 26 minutes. G. glabra extract was orally administered in 200 mg/kg body weight capsules per day.Results: IL-1β and TNF-α levels significantly decreased in training and G. glabra-treated groups but their decrease were more marked in training+G. glabra-treated group (P < 0.05). Cognitive state in three intervention groups significantly improved compared to placebo group, and this improvement was more marked in training+G. glabra-treated group (P < 0.05).Conclusion: Consumption of G. glabra extract with aerobic training for 12 weeks can slow down or stop the progression of MCI in the elderly through improving their cognitive states probably via decreasing inflammatory factors.

Key words
Aerobic training, Glycyrrhiza glabra, Cognitive state, Inflammation, Cognitive impairment


Comments
First name  
Last name  
Email address  
Comments  
Security code



Article
PDF


Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks

Cite by
Google Scholar


Google Scholar
Articles by Mohammad-Ali Kohanpour
Articles by Maghsoud Peeri
Articles by Mohammad-Ali Azarbayjani
Similar articles
Related articles

PubMed
Articles by Mohammad-Ali Kohanpour
Articles by Maghsoud Peeri
Articles by Mohammad-Ali Azarbayjani


Article Access Statistics
Viewed
PDF Downloaded
Comments

Share this article!
Creative Commons Attribution 4.0 License This work is licensed under a Creative Commons Attribution 4.0 License.
Copyright © 2015 by Journal of Herbmed Pharmacology (JHP)