J Herbmed Pharmacol. 2017;6(1):16-20.
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Original Article

The effect of silymarin on non-alcoholic fatty liver disease of children

Fatemeh Famouri 1, 2 * , Mohammad-Mehdi Salehi 1, Nooshin Rostampour 3, Elham Hashemi 1, Armindokht Shahsanaee 1

1 Department of Pediatrics, Shahrekord University of Medical Science, Shahrekord, Iran
2 Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Medical Plants Research Center, Shahrekord University of Medical Science, Shahrekord, Iran

Abstract

Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases of adults and its prevalence is increasing in children and adolescents. It is the most predisposing factor for liver cirrhosis. Due to complications of NAFLD, the treatment of this disease is essential. Since silymarin is recommended for adults recently, the effect of this herbal drug on children and adolescents was evaluated for treatment of NAFLD in children.Methods: This is a clinical trial study, which was done in Shahrekord University of Medical Science in 2012-2013 on 5-16 years old children with NAFLD. The patients were randomly divided into two groups containing 20 patients in each group. Silymarin tablets were administered for 12 weeks in case group and changing life style including exercise was advised in both groups. Liver sonographay and liver function tests (LFTs) were done after 12 weeks.Results: Patients with higher grade of fatty liver were developed lower grade of fatty liver during intervention in case group based on sonography after 12 weeks (P = 0.001). Meanwhile, no significant changes were observed in control group (P = 0.35). Liver enzymes (alanine aminotransferase [ALT] and aspartate transaminase [AST]) (P = 0.001, P = 0.025, respectively) and triglyceride (TG) levels (P = 0.043) were improved significantly but low-density lipoprotein (LDL) and high-density lipoprotein (HDL) did not change during intervention in case group.Conclusion: Silymarin can improve fatty infiltration of liver and liver function in children and adolescents.

Implication for health policy/practice/research/medical education:

Silymarin can improve fatty infiltration of liver and liver function in children and adolescents, hence it might be beneficial for NAFLD patients.

Please cite this paper as:

Famouri F, Salehi MM, Rostampour N, Hashemi E, Shahsanaee A. The effect of silymarin on non-alcoholic fatty liver disease of children. J Herbmed Pharmacol. 2017;6(1):16-20.

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Revised: 20 Nov 2016
First published online: 12 Dec 2016
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