Shahrekord University of Medical Sciences Journal of Herbmed Pharmacology 2345-5004 15 1 2026 01 01 A comprehensive review on radioprotective potency and multifaceted biological activities of gallic acid 1 10 10.34172/jhp.2026.52846 EN Zahra Shaghaghi https://orcid.org/0000-0002-7467-4820 Saeedeh Zamani https://orcid.org/0000-0002-8372-6354 Farzad Fathi https://orcid.org/0009-0007-4681-7648 Maryam Alvandi https://orcid.org/0000-0002-1829-5068 Fatemeh Kholoosi Taher https://orcid.org/0009-0008-3929-0398 Mohammad Reza Dehbanpour https://orcid.org/0000-0001-8892-642X Roozbeh Narimani Javid https://orcid.org/0000-0002-9134-8787 Journal Article 10.34172/jhp.2026.52846 2024 12 01 2025 05 18 This review really digs into all the cool ways gallic acid (GA) can help with health, especially its strong powers in fighting off damage from oxygen radicals and stopping cancer from growing. We dive deep into how GA messes with different cancer cells, making them die off in a controlled way. The presentation also discusses how gallium enhances the efficacy of chemotherapeutic drugs, serving as a robust protective barrier against the adverse effects of chemotherapy. Moving on, we look at how GA helps protect the body from harm caused by radiation or other toxic substances, especially in important parts like the liver, kidneys, and brain. But GA’s not just about cancer; it’s also great at protecting the nerves, keeping blood vessels healthy, and even stopping diseases before they start. By the end, we get a full picture of how GA moves around the body, how it gets broken down, and all the ways it can protect the body, making it a really interesting natural substance for medical use. As no thorough study has yet explored this topic, this review seeks to comprehensively evaluate the most prominent research on the diverse biological activities of GA, including its radioprotective effects.