Shahrekord University of Medical Sciences Journal of Herbmed Pharmacology 2345-5004 14 1 2025 01 01 Toothache plant: A comprehensive review focusing on its applications in dental health 1 10 10.34172/jhp.2025.51533 EN Soumya Subhashree Satapathy https://orcid.org/0000-0002-2942-7644 Ruchi Bhuyan https://orcid.org/0000-0002-4082-8393 Arun Kumar Pradhan https://orcid.org/0000-0002-6057-073X Nihar Ranjan Panda https://orcid.org/0000-0002-3483-1433 Sanat Kumar Bhuyan https://orcid.org/0000-0002-5460-3750 Journal Article 10.34172/jhp.2025.51533 2024 04 03 2024 05 30 The contemporary era showcases a growing emphasis on alternative medicine, specifically the utilization of ethnomedicine, which has gained significant attraction in recent times. This review explores the curative properties and ethnomedicinal utilization of the "Toothache plant" belonging to the Asteraceae family, the most common weed in crop fields. "Toothache plant" has added noteworthy attention in dentistry due to its unique properties. The toothache plant is well-known for providing numbing and analgesic effects by simply chewing the flowers due to the presence of active compounds such as Spilanthol. The analgesic property makes the plant a potential candidate for natural pain relievers, particularly in dentistry. Besides its dental application, this plant is used as an antidote for snake bites. This review summarises the ethnomedicinal values and clinical applications of the toothache plant, with a particular focus on oral health care, and the findings presented herein are anticipated to help in future research.