Shahrekord University of Medical Sciences Journal of Herbmed Pharmacology 2345-5004 13 3 2024 07 01 Extraction, phytochemicals, bioactivities, and toxicity of Syzygium polyanthum: A comprehensive review 366 380 10.34172/jhp.2024.51454 EN Nurlely Nurlely https://orcid.org/0000-0003-4103-4090 Aditya Maulana Perdana Putra https://orcid.org/0000-0003-3444-4059 Arief Nurrochmad https://orcid.org/0000-0001-7597-2574 Sitarina Widyarini https://orcid.org/0000-0003-4461-8454 Nanang Fakhrudin https://orcid.org/0000-0001-7954-9503 Journal Article 10.34172/jhp.2024.51454 2024 02 09 2024 04 23 Medicinal plants are receiving much attention because they are traditionally used to treat common diseases. Syzygium polyanthum, an important medicinal plant, has been widely used in Southeast Asia, and numerous studies have published its chemical constituents and biological properties. Therefore, this study aimed to present the results of previous studies on extraction methods, chemical contents, and bioactivities of S. polyanthum published between 2011 and 2023. Some solvents have been predominantly used in the extraction of S. polyanthum, such as methanol, ethanol, ethyl acetate, n-hexane, and water. Maceration was the most commonly used method, followed by Soxhlet extraction, hydro-distillation, percolation, decoction, infusion, ultrasound-assisted extraction, and rapid solvent extraction. Furthermore, bioactivities of S. polyanthum, such as antioxidant, antihypertensive, antihyperglycemic, antibacterial, antifungal, cytotoxic, and antidementia properties, were reported. However, in the toxicity studies, no toxicity signs were observed after extended administration. Therefore, S. polyanthum might be an alternative natural product in treating some diseases. It also might be the main therapy when appropriate extraction method and solvent are used.