Shahrekord University of Medical Sciences Journal of Herbmed Pharmacology 2345-5004 11 4 2022 10 01 Antianaemic property of Ficus capensis leaves and its combination with Cnidoscolus aconitifolius leaves in phenylhydrazine-induced anemic rats 503 512 10.34172/jhp.2022.58 EN Obiajulu Christian Ezeigwe https://orcid.org/0000-0002-5416-6079 Chidinma Felicia Ezennaya https://orcid.org/0000-0002-2945-4925 Ebele Lauretta Iloanya https://orcid.org/0000-0003-0601-0421 Chioma Henrietta Obi https://orcid.org/0000-0002-4318-7659 Nma Helen Ifedilichukwu https://orcid.org/0000-0001-7538-8888 Chisom Miracle Okeke https://orcid.org/0000-0001-9780-8943 Journal Article 10.34172/jhp.2022.58 2022 04 14 2022 07 02 Introduction: Anemia is a common health condition caused by a decrease in red blood cells. Some medicinal plants are used as a remedy to treat anemia. This study compares the anti-anemic properties of different doses of the aqueous extracts of Ficus capensis (AEFC) and its combination with the aqueous extract of Cnidoscolus aconitifolius (AECA) in phenylhydrazine-induced anemic rats. Methods: Anemia was induced by intraperitoneal injection of 20 mg/kg phenylhydrazine for five consecutive days. Graded doses of the extracts were given by oral gavage once a day continuously for 30 days. At the end of the treatment, blood was collected for hematological analysis. Results: The antianemic effects of AEFC and its combination with AECA were demonstrated by significant increases (P < 0.05) in the hemoglobin (HGB), packed cell volume (PCV) and red blood cell (RBC) count of the extract-treated groups compared to the anemic control group. There was a better increase in the HGB levels of a combination of 400 mg/kg AEFC + AECA (13.97 ± 2.53) compared to 400 mg/kg AEFC (12.06 ± 0.02). The PCV increased more in 400 mg/kg combination of AEFC + AECA (41.94 ± 0.37) compared to 400 mg/kg AEFC (36.31 ± 1.51). A significant (P < 0.05) increase was observed in the RBC count of a combination of 400 mg/kg AEFC + AECA (6.36±0.51) compared to 400 mg/kg AEFC (4.75 ± 0.46). Conclusion: Although AEFC improved the haematological parameters of the animals when administered alone, its combination with AECA yielded a far much better result by totally restoring the haematological parameters of the phenylhydrazine-induced anemic rats to normal.