Shahrekord University of Medical Sciences Journal of Herbmed Pharmacology 2345-5004 11 3 2022 07 01 Ruta montana (L.) L.: An insight into its medicinal value, phytochemistry, biological properties, and toxicity 305 319 10.34172/jhp.2022.36 EN Nesrine Benkhaira https://orcid.org/0000-0002-4507-6661 Saad Ibnsouda Koraichi https://orcid.org/0000-0001-6320-7381 Kawtar Fikri-Benbrahim https://orcid.org/0000-0002-2923-9299 Journal Article 10.34172/jhp.2022.36 2022 02 11 2022 03 29 Ruta montana (RM) is a medicinal and aromatic plant (MAP) used in folk medicine, especially in North Africa, to treat digestive, infectious, respiratory, neurological, gynecological, and diabetic diseases. The current work aims to review the scientifically validated ethno-medicinal usage, bioactivities and phytochemistry of RM, in order to provide data support for further investigations. Data were procured from PubMed, Scopus, Google Scholar, Web of Science, ScienceDirect, and PubChem. The present study revealed that RM could be used to manage many diseases involved in public health problems, such as diabetes, hypertension, neurological disorders, infections, reproductive system disorders, and cancer. It might also replace chemical insecticides and fungicides since it exhibits antifungal, insecticidal, and larvicidal properties. RM extracts also contain mainly coumarins and alkaloids. The volatile oil of RM is characterized by an abundance of ketone compounds and 2-undecanone as major constituents. In the case of a high-dose administration, RM infusion can cause poisoning through the oral path. Thus, in-depth in vivo pharmacological studies and clinical trials are needed to transmute the traditional applications of RM into scientific-based information.