Shahrekord University of Medical Sciences Journal of Herbmed Pharmacology 2345-5004 10 2 2021 04 01 The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agent: proposed mechanisms based on a systematic review 166 178 10.34172/jhp.2021.18 EN David Andi Wijaya https://orcid.org/0000-0001-8125-0236 Melva Louisa https://orcid.org/0000-0002-9451-0380 Heri Wibowo https://orcid.org/0000-0001-7708-5135 Aslim Taslim https://orcid.org/0000-0002-1866-5014 Tiara Bunga Mayang Permata https://orcid.org/0000-0002-5890-5545 Handoko Handoko https://orcid.org/0000-0002-2834-9090 Endang Nuryadi https://orcid.org/0000-0003-1029-1748 Henry Kodrat https://orcid.org/0000-0003-3782-7901 Soehartati Argadikoesoema Gondhowiardjo https://orcid.org/0000-0002-9446-4361 Journal Article 10.34172/jhp.2021.18 2020 07 11 2020 09 29 Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent.