Shahrekord University of Medical Sciences Journal of Herbmed Pharmacology 2345-5004 8 2 2019 03 15 Genotoxic potential of selected medicinal plant extracts in human whole blood cultures 160 162 10.15171/jhp.2019.25 EN Karina Harutyunyan https://orcid.org/0000-0002-3274-1239 Karine Balayan Gohar Tadevosyan Manush Hayrapetyan Ruzanna Musayelyan Ruzanna Grigoryan Lusine Khondkaryan Natalya Sarkisyan Nelly Babayan https://orcid.org/0000-0001-9205-7693 Journal Article 10.15171/jhp.2019.25 2018 08 16 2018 11 16 Introduction: Many plant-derived products despite wide usage are not scientifically evaluated for their safety and efficacy. Therefore, in the present study, we aimed to evaluate the cytotoxic and genotoxic activities of Polygonum aviculare L., Equisetum arvense L., Plantago lanceolata L. and Artemisia absinthium L. ethanolic extracts in human white blood cells. Methods: Cell viability was assayed by trypan blue exclusion method, while the genotoxicity was tested by cytokinesis-block micronucleus (CBMN) assay upon cells stimulation with noncytotoxic concentrations of the plant extracts. Results: None of the plant extracts showed high cytotoxic activity. At the same time, only extract of P. lanceolata did not present any mutagenic activity, while E. arvense, P. aviculare and A. absinthium were clearly genotoxic. Conclusion: Caution is advice in the case of long-term use of E. arvense, P. aviculare and A. absinthium herbal medicines by population.