Shahrekord University of Medical Sciences Journal of Herbmed Pharmacology 2345-5004 5 4 2016 10 01 Haplophyllum tuberculatum: An overview 125 130 EN Abdolshakoor Raissi Mina Arbabi Javad Roustakhiz Masih Hosseini Journal Article Introduction: Haplophyllum tuberculatum, belonging to the Rutaceae family, is distributed in south-eastern regions of Iran, particularly in Baloochestan. This study was aimed to investigate and collect scientific reports such as morphological characteristics, phytochemical compounds, ecology, biotechnology and evaluation of the therapeutic properties of this valuable medicinal plant.Methods: In order to gather the information the keywords Haplophyllum tuberculatum, botany, genetic, biotechnology, therapeutic, and pharmacology were searched until 2016 from journals accessible in databases such as Scopus, EBSCO, Science Direct, Medline, PubMed, Embase, SID and Iran Medex.Results: The results in this study revealed various pharmacological properties including anti-cancer, antioxidantant, uterus-relaxing, anti-bacterial and anti-HIV activities for this plant which are probably due to the presence of aromatic compounds such as two alkaloids named haplophytin-a and B, and essential oils.Conclusion: Haplophyllum tuberculatum possesses various pharmacological properties and the bioactive molecules of this plant play an important role in human health, hence, it might be used for different drug productions.